THE CLINICAL USE OF THE URINARY G1 CELL CYCLE ARREST BIOMARKER { TIMP-2} FOR EARLY PREDICTION OF ACUTE KIDNEY INJURY IN CRITICALLY ILL CHILDREN
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2018, Vol 3, Issue 6
Abstract
BACKGROUND: Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill population, with devastating short- and long-term consequences , and its incidence is rising at an alarming rate . Tissue inhibitor of metalloproteinase-2 (TIMP-2) was reported as an emerging biomarker for predicting severe AKI in critically ill patients METHODS: This Prospective case control studywas conducted on 60 critically illchildren of both sex admitted to PICU of Benha children Hospital and 20 healthy control group of both sex. The study was conducted during the period from September 2016 to December 2016 . All cases were followed up for 2 months or until they improved or died. The study group was devided into 3 groups Acute kidney injury group (AKI gp) : critically ill with AKI included 36 patients , Non Acute kidney injury group(Non AKI gp) : critically ill without AKI included 24 patients , Control group : control group comprised 20 apparently healthy children matched in age and sex with patient groups . AKI etiologies were: dehydration/hypovolemia (n = 5) , hemodynamic instability (n = 9), septic shock (n =20) vasculitis (n= 2) RESULTS: There was statistical signicant difference between the studied groups regarding serum TIMP 2 day 1 as it was higher in AKI group than non AKI group than control group CONCLUSIONS: TIMP-2 can be used as a urinary biomarker for early detection of acute kidney injury (AKI) in critically ill patients
Authors and Affiliations
Mohammed S. Selim, Soha A. Ibrahim, Ola G. Behairy, Eman Ramadan, Ghada A. Ibrahim
Keywords
Related Articles
- EP ID EP598362
- DOI -
- Views 45
- Downloads 0
ROLE OF PLATELET RICH PLASMA IN TREATMENT OF ROTATOR CUFF TENDINOPATHY AND PARTIAL THICKNESS TEAR: FOLLOW UP BY ULTRASOUND
The pathophysiology of RCT is characterized by progressive, degenerative changes within the tendon as a result of overuse, altered shoulder mechanics, and a limitation of the normal tendon repair system with a broblasti...
EFFECT OF MDR1 GENE POLYMORPHISMS ON RESPONSE TO ORAL PREDNISOLONE IN EGYPTIAN IMMUNE THROMBOCYTOPENIC PATIENTS
Immune thrombytopenia(ITP) is an autoimmune disorder characterized by heterogeneous bleeding manifestations as well as marked-inter individual variation in response to glucocorticoid (GCs); the 1st line ITP treatment. Th...
EFFECTIVENESS USING GABAPENTIN TOWARD PAIN INTENSITY DECREASED & LIFE QUALITY OF DIABETIC NEUROPATHY PATIENTS AT NEUROLOGY UNIT – REGIONAL PUBLIC HOSPITAL, WEST NUSA TENGGARA PROVIN
Diabetic neuropathy pain is one of the microvascular complications due to prolonged hyperglycemia which results in disruption of peripheral blood ow. Because chronic pain often makes patients frustrated causing the qual...
COMPARISON OF SCLERAL THICKNESS AND FIBROBLAST IN FORM DEPRIVATION ANIMAL MODEL (EXPERIMENTAL STUDY OF WISTAR RAT)
Background Form deprivation (FD) is an effective approach to induce animal models of myopia. In this investigation deprived of form vision compared to the fellow, non-deprived eye by histopathology of scleral thickness a...
EVALUATION OF CONTROL OF DIABETES MELLITUS IN HEMODIALYSIS PATIENTS: PERSPECTIVE STUDY
Management of diabetes includes many areas that may be inuenced by the severity of a patient's kidney dysfunction. This includes the methods that are used to determine the adequacy of diabetes control, such as hemoglobi...