The comparison of early and late effectiveness of systemic and high dose inhaled glucocorticoids in the management of acute asthma attacks in children
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 1
Abstract
Objective: In this study it was aimed to compare effectiveness of systemic steroids and inhaled corticosteroids in children who applied with acute asthmatic attack. Materials and methods: Children with acute asthmatic attack were randomly allocated to two groups; 1 mg/kg per oral methylprednisolone was given to Group 1 (Systemic steroid group, n=27), and 4000 μg inhaled fluticasone to Group 2 (Inhaled steroid group, n=35). Following treatment patients were evaluated for four hours, at one-hour intervals by asthma score, forced expiratory volume in first-second (FEV1) and peak expiratory flow (PEF). Primary outcome of this study was the rate of hospital admissions and secondary outcome were asthma score, FEV1, PEF and oxygen saturation. Results: Significant improvements were obtained in measured parameters in both Group 1 and Group 2. Values of measured parameters at hospital admission, 4th hour of treatment and while patients were in comfort were as follow: PEF values (Group 1: 173, 223, 220 L/min, p <0.001): Group 2 113, 141 , 192 L/min, p <0.001); FEV 1 (Group 1: 74.9%, 89.5%, 85.6%, p <0.0001; Group 2: 96, 89.8, 93.2 %, p <0.0001); O2 saturation (Group 1:93.2%, 95.6%, 96.8%, p <0.0001, Group 2: 93%, 95.2%, 96.6%, p<0.001); and asthma score (Group 1: 9.4, 6.6, 5.7, p<0.001, Group 2: 9.3, 6.8, 6.5, p<0.001). In all measured parameters significant improvements were observed with treatment modalities within both groups. No significant differences were found in all parameters between Group 1 and Group 2 (p>0.05). Conclusion: No significant differences were found in asthma score, FEV 1 and PEF parameters between systemic high-dose methylprednisolone and inhaled fluticasone treatment modalities in acute asthmatic attacks of children. Key words: Asthma, asthma exacerbation, inhaled fluticasone, systemic corticosteroid
Authors and Affiliations
Ünal Uluca, Özlem Keskin, Bülent Gögebakan, Sinan Balaban, Mehmet Keskin, Ercan Küçükosmanoğlu
Trombotik trombositopenik purpura ile eş zamanlı otoimmün tiroidit
Trombotik trombositopenik purpura (TTP); mikrosirkulasyonda localize yaygın trombotik tıkanıklıklar, mikroangiopatik hemolitik anemi, trombositopeni, ateş, renal ve nörolojik anormallikler ile karakterizedir. 14 yaşında...
[u][/u]Epidemiology and Endoscopic Findings of the Patients Suffering from Upper Gastrointestinal System Bleeding
Objective: In the present study, we aim to investigate general and endoscopic findings of the patients who were hospitalized in our clinic because of upper gastrointestinal system bleeding (UGSB). Methods: The files of...
Nadir görülen bir böbrek tümörü: Müsinöz tübüler ve iğsi hücreli karsinom
Müsinöz tübüler ve iğsi hücreli karsinom yakın geçmişte tanımlanmış, nadir görülen bir böbrek tümörüdür. Literatürde tek olgu veya küçük olgu serileri şeklinde bildirilmiştir. Tümör düşük dereceli, rölatif olarak i...
Yetişkin Türk toplumunda ağız yanması sendromu prevalansı
Ağız yanması sendromu (AYS) kronik bir orofasiyal ağrı olarak tanımlanır ve semptomatik olarak dilde ve dudakta veya bütün ağız boşluğu içinde yangı tarzında bir ağrıyla karakterizedir. Uluslararası çalışmalarda Ağız yan...
p53 ve p53 gen ailesi üyeleri olan p63 ve p73’ün hücresel işlevleri
p53, hücre akıbetinin belirlenmesinde önemli rol oynayan hücre döngüsünün durdurulması veya programlı hücre ölümüne yönlendirilmesi gibi hücresel birçok yolağın düzenlenmesinde görev alan bir transkripsiyon faktörüdür. p...