The comparison of early and late effectiveness of systemic and high dose inhaled glucocorticoids in the management of acute asthma attacks in children
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 1
Abstract
Objective: In this study it was aimed to compare effectiveness of systemic steroids and inhaled corticosteroids in children who applied with acute asthmatic attack. Materials and methods: Children with acute asthmatic attack were randomly allocated to two groups; 1 mg/kg per oral methylprednisolone was given to Group 1 (Systemic steroid group, n=27), and 4000 μg inhaled fluticasone to Group 2 (Inhaled steroid group, n=35). Following treatment patients were evaluated for four hours, at one-hour intervals by asthma score, forced expiratory volume in first-second (FEV1) and peak expiratory flow (PEF). Primary outcome of this study was the rate of hospital admissions and secondary outcome were asthma score, FEV1, PEF and oxygen saturation. Results: Significant improvements were obtained in measured parameters in both Group 1 and Group 2. Values of measured parameters at hospital admission, 4th hour of treatment and while patients were in comfort were as follow: PEF values (Group 1: 173, 223, 220 L/min, p <0.001): Group 2 113, 141 , 192 L/min, p <0.001); FEV 1 (Group 1: 74.9%, 89.5%, 85.6%, p <0.0001; Group 2: 96, 89.8, 93.2 %, p <0.0001); O2 saturation (Group 1:93.2%, 95.6%, 96.8%, p <0.0001, Group 2: 93%, 95.2%, 96.6%, p<0.001); and asthma score (Group 1: 9.4, 6.6, 5.7, p<0.001, Group 2: 9.3, 6.8, 6.5, p<0.001). In all measured parameters significant improvements were observed with treatment modalities within both groups. No significant differences were found in all parameters between Group 1 and Group 2 (p>0.05). Conclusion: No significant differences were found in asthma score, FEV 1 and PEF parameters between systemic high-dose methylprednisolone and inhaled fluticasone treatment modalities in acute asthmatic attacks of children. Key words: Asthma, asthma exacerbation, inhaled fluticasone, systemic corticosteroid
Authors and Affiliations
Ünal Uluca, Özlem Keskin, Bülent Gögebakan, Sinan Balaban, Mehmet Keskin, Ercan Küçükosmanoğlu
Keywords
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- EP ID EP135691
- DOI doi: 10.5798/diclemedj.0921.2013.01.0230
- Views 108
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