The comparison of early and late effectiveness of systemic and high dose inhaled glucocorticoids in the management of acute asthma attacks in children

Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 1

Abstract

Objective: In this study it was aimed to compare effectiveness of systemic steroids and inhaled corticosteroids in children who applied with acute asthmatic attack. Materials and methods: Children with acute asthmatic attack were randomly allocated to two groups; 1 mg/kg per oral methylprednisolone was given to Group 1 (Systemic steroid group, n=27), and 4000 μg inhaled fluticasone to Group 2 (Inhaled steroid group, n=35). Following treatment patients were evaluated for four hours, at one-hour intervals by asthma score, forced expiratory volume in first-second (FEV1) and peak expiratory flow (PEF). Primary outcome of this study was the rate of hospital admissions and secondary outcome were asthma score, FEV1, PEF and oxygen saturation. Results: Significant improvements were obtained in measured parameters in both Group 1 and Group 2. Values of measured parameters at hospital admission, 4th hour of treatment and while patients were in comfort were as follow: PEF values (Group 1: 173, 223, 220 L/min, p <0.001): Group 2 113, 141 , 192 L/min, p <0.001); FEV 1 (Group 1: 74.9%, 89.5%, 85.6%, p <0.0001; Group 2: 96, 89.8, 93.2 %, p <0.0001); O2 saturation (Group 1:93.2%, 95.6%, 96.8%, p <0.0001, Group 2: 93%, 95.2%, 96.6%, p<0.001); and asthma score (Group 1: 9.4, 6.6, 5.7, p<0.001, Group 2: 9.3, 6.8, 6.5, p<0.001). In all measured parameters significant improvements were observed with treatment modalities within both groups. No significant differences were found in all parameters between Group 1 and Group 2 (p>0.05). Conclusion: No significant differences were found in asthma score, FEV 1 and PEF parameters between systemic high-dose methylprednisolone and inhaled fluticasone treatment modalities in acute asthmatic attacks of children. Key words: Asthma, asthma exacerbation, inhaled fluticasone, systemic corticosteroid

Authors and Affiliations

Ünal Uluca, Özlem Keskin, Bülent Gögebakan, Sinan Balaban, Mehmet Keskin, Ercan Küçükosmanoğlu

Keywords

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  • EP ID EP135691
  • DOI doi: 10.5798/diclemedj.0921.2013.01.0230
  • Views 107
  • Downloads 0

How To Cite

Ünal Uluca, Özlem Keskin, Bülent Gögebakan, Sinan Balaban, Mehmet Keskin, Ercan Küçükosmanoğlu (2013). The comparison of early and late effectiveness of systemic and high dose inhaled glucocorticoids in the management of acute asthma attacks in children. Dicle Tıp Dergisi, 40(1), 86-94. https://europub.co.uk/articles/-A-135691