The comparison of Magnesium Sulfate and Ritodrine Hydrochloride for management of preterm labor
Journal Title: Dicle Tıp Dergisi - Year 2012, Vol 39, Issue 2
Abstract
Objectives: We aimed to compare the efficacy, and maternal and fetal outcomes of magnesium sulfate and ritodrine hydrochloride treatments in preterm labor. Materials and methods: Eighty pregnant women with premature labor between 28 and 36 weeks of pregnancy were divided into two groups randomly. One group received magnesium sulfate and the other received ritodrine hydrochloride. Preterm labor was defined as the occurrence of at least two contractions in 10 minutes accompanied by cervical changes. Magnesium sulfate was administered as a 4,5 gram bolus, then continued 1-2 gr/h infusion rate. Ritodrine hydrochloride was started 50 mcg/ minute infusion, and was increased to 50 mcg/minute every 15-20 minutes until the contractions stops or occurs the serious side effects. The intravenous treatments with both agents were continued with oral maintenance therapy. Tocolytic effect and maternal-fetal outcomes were statistically compared. Results: There was no significant difference between both tocolytic treatment groups in terms of the prolongation of pregnancy ≥ 48 hours and ≥ 7 days, termination of pregnancy after 36 weeks, the delayed the number of days after onset of preterm labor and gestational weeks at the birth. Life-threatening serious adverse effects were not observed in both groups. Side effects were less observed in magnesium sulfate group. No significant difference was found in newborn weight and apgar scores between two groups. Conclusion: There is no difference between these two treatments for efficacy, fetal and neonatal outcomes. However, considering the maternal adverse effects, magnesium sulfate treatment is superior to ritodrine hydrochloride.
Authors and Affiliations
Hatice Soydinç, Gonca Yıldırım, Metin Nurluoğlu
Keywords
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