The correlation between nesfatin-1 and blood pressure in healthy normal weight and obese adults
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2014, Vol 8, Issue 3
Abstract
Nesfatin-1 is an anorexigenic peptide with 82 aminoacides expresses in hypothalamic cells, adipose tissue, gastric mucous and pancreatic ?-cells. Its precursor protein is named nucleobindin-2 (NUCB2). Recently it is suggested that nesfatin-1 my influence blood pressure both via direct effect on vessels and by affecting central nervous system. This is the first study to investigate the association between blood pressure and nesfatin-1 serum level in normal weight and obese subjects considering the nesfatin-1 as an adipokine. The study population consists of 40 obese and 40 normal weight individuals who did not have any significant disease in their medical history. Despite the significant difference in blood pressure in both groups (systolic and diastolic blood pressure in the normal group were respectively 106.50±11.88 and 73.75±11.91 mmHg and in the obese group were respectively 115.25±12.75 and 80.50±9.59 mmHg) no significant correlation was observed between nesfatin-1 serum level and blood pressure (P<0.05). Despite the previous observations indicating nesfatin-1 role in regulating blood pressure our results did not show any correlation between nesfatin-1 serum level and blood pressure in obese and normal weight group. It is speculated that the obesity related resistance in transferring nesfatin-1 to the CNS may cause the lack of association between nesfatin-1 and blood pressure.
Authors and Affiliations
Nazanin Khamin Hamedani| Department of Clinical Nutrition, International Campus, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran, Mohammad Javad Hosseinzadeh-Attar *| Department of Clinical Nutrition, International Campus, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran, Endocrine and Metabolism Research Center (EMRC), Obesity and Food Group Set, Tehran University of Medical Sciences, Tehran, IR Iran, email: hosseinzadeh.md.phd@gmail.com, Mostafa Hosseini| Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Keywords
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