The correlation of TAS2R38 gene variants with higher risk for chronic rhinosinusitis in Polish patients
Journal Title: Otolaryngologia Polska - Year 2016, Vol 70, Issue 5
Abstract
Background: Bitter taste receptors (T2Rs), especially T2R38s appear as innovative regulators of innate immunity in the respiratory system. The single nucleotide polymorphisms (SNPs) in TAS2R38 gene may contribute to individual differences in susceptibility to respiratory infections especially chronic rhinosinusitis (CRS). TAS2R38 genotypes distribution varies by geographic region, race and ethnicity. The aim of the preliminary study was the identification of SNPs in TAS2R38 encoding genes in Polish patients with CRS and finding potential correlation with CRS phenotypes. Material and methods: The preliminary study contained 20 CRS patients undergoing functional endoscopic sinus surgery (FESS). Fresh sinus mucosa (SM) was obtained during FESS in CRS patients. Patients were genotyped for TAS2R38 using Sanger method and the genotype occurrences of the clinically recalcitrant CRS cohort was evaluated. Analysis of TAS2R38 expression in SM of CRS patients was performed using immunohistochemistry (IHC). Results: T2R38 was highly expressed in SM of CRS patients. Patients with CRS demonstrated both common genotypes PAV, AVI. The heterozygotes frequency (AVI/PAV) was the highest. The protective genotype (PAV/PAV) was noticed in the lowest frequency and connected with lower average value of CT score compare to AVI/AVI genotypes (p=0.01). Conclusions: The work presented in this study provides the hypothesis that airway bitter T2Rs are an innovative sphere of human respiratory innate protection. TAS2R38 polymorphism may influence the susceptibility to CRS. The AVI haplotypes are an independent risk factors for CRS. Additionally, the bitter taste receptors and related signalling pathways might create an unique group of therapeutic targets to treat CRS.
Authors and Affiliations
Karolina Dżaman, Mariola Zagor, Elżbieta Sarnowska, Antoni Krzeski, Ireneusz Kantor, Beata Bilińska
Keywords
Related Articles
- EP ID EP79039
- DOI 10.5604/00306657.1209438
- Views 102
- Downloads 0
Correlation of auditory-verbal skills in patients with cochlear implants and their evaluation in Positone Emission Tomography (PET)
SUMMARY Introduction: An assumption was taken that in central nervous system (CNS) in patients above 15 years of age there are possible mechanisms of neuronal changes. Those changes allow for reconstruction or formation...
Porażenia krtani w materiale Poradni Foniatrycznej Warszawskiego Uniwersytetu Medycznego w latach 2000-2011
Tonsillektomia z zastosowaniem skalpela harmonicznego – doświadczenie własne i przegląd literatury
Introduction. The harmonic scalpel has been used in tonsil surgery for several years. The comparison of harmonic scalpel tonsillectomy with other tonsillectomy techniques has been the subject of many studies. The researc...
Ropowica głowy jako powikłanie róży powiek – dwa przypadki w jednej rodzinie
Introduction. Bacterial infections of skin and subcutaneous tissue are not rare, but they are connected with diagnostic and therapeutic diffi culties. Aim. A case of almost simultaneous facial phlegmon in course of eyeli...
Ocena korelacji średniego ciśnienia tętniczego z krwawieniem śródoperacyjnym przy wolnej czynności serca w trakcie endoskopowej chirurgii zatok przynosowych
Induced controlled hypotension is a standard method aimed at decreasing intraoperative bleeding and achieving good operative field conditions. Low hemodynamic parameters during the operation are related to increased risk...