The correlations between the clinical and anamnestic characteristics and biochemical parameters of bone tissue metabolism at the comorbidity of chronic pancreatitis and arterial hypertension
Journal Title: Український терапевтичний журнал - Year 2019, Vol 0, Issue 3
Abstract
Objective — to establish the presence of correlations between the clinical and anamnestic characteristics of patients and biochemical indicators of bone tissue metabolism, as well as the presence of fractures in patients with a combined course of chronic pancreatitis (CP) and arterial hypertension (AH). Materials and methods. The examinations involved 110 patients with CP, among them 40 patients had an isolated CP course, and 70 subjects had concomitant AH. The diagnostic search included clinical and anamnestic characteristics of patients (gender, age, disease duration, level of pancreatic elastase 1) and biochemical parameters of bone tissue metabolism (osteocalcin, total acid phosphatase (TAP) and tartrate-resistant acid phosphatase (TRAP)), as well as fractures with the determination of correlations between these indicators in patients with CP and AH and the formation of complications. The control group consisted of 78 gender- and age-matching healthy individuals. Results and discussion. Determining the links between the clinical and anamnestic characteristics of patients and the biochemical parameters of bone tissue metabolism allowed to reveal the high (R = 0.60) significant (p < 0.01) correlation between the osteocalcin levels and the level of pancreatic elastase in the group with isolated CP. Moreover, the negative significant (p < 0.01) correlation of the average strength (R = –0.49) between the TRAP levels and patient’s age has been established. In patients with comorbid CP and AH pathology, the relationship of moderate strength between the TRAP and the AH duration was significant (R = 0.36, p < 0.01). The levels of TAP and TRAP exceeded the normal values in individuals of the main group in 2.5 and 1.9 times (KMU; U = 866.0; p < 0.01), and in the comparison group in 2.0 (TAP) and 1.3 (TRAP) times, respectively (KMU; U = 821.0; p < 0.01), testifying the development of osteopenic states. Conclusions. The formation and course of CP, and especially its combination with hypertension, contributes to the early disruption of the structural and functional state of the bone tissue, which is confirmed by the frequent occurrence of limb fractures. In patients with CP, there is a positive correlation between the levels of osteocalcin and pancreatic elastase 1, indicating the relationship between the impaired exocrine pancreatic function and disorders of bone metabolism. An increase in the activity TAP and TRAP takes place both at the isolated course of CP, and in comorbidity of CP and AH, it can be considered as a marker of the formation of osteopenia syndrome.
Authors and Affiliations
T. I. Viun
Keywords
Related Articles
- EP ID EP668745
- DOI 10.30978/UTJ2019-3-47
- Views 59
- Downloads 0
Age-related aspects of bone tissue condition at chronic pancreatitis
The fact that chronic pancreatitis (СP) affects mostly patients of employable age is one of the important factors of its social significance. Objective — to study the state of bone tissue of patients with СP of various a...
The peculiarities of the treatment of patients with arterial hypertension and type 2 diabetes mellitus
Currently, arterial hypertension is established in more than a half of patients with diabetes. The presence of comorbid diseases requires an optimal treatment approach. The article provides an overview of current guideli...
Biochemical peculiarities of liver injury in patients with acute lymphoblastic leukemia of standard risk
The specific chemotherapy (CT) in patients with acute lymphoblastic leukemia (ALL) is accompanied by a risk of the liver functional state violation. However, there are still many unsolved questions regarding the hepatoto...
Sarcopenia as a risk factor for chronic noncommunicable diseases
The article presents the summary of data related to the modern diagnosis of sarcopenia and management of patients with this disease. The actuality of the problem has been demonstrated, as well the difficulties of sarcope...
The effects of prolactin on ADP-induced platelet aggregation in patients with stable angina of effort and gastroesophageal reflux disease
The combination of stable angina of effort (SEA) and gastroesophageal reflux disease (GERD) is frequently observed in the clinic of internal diseases. Thrombocytic link of homeostasis is one of the main factors in the de...