THE DIAGNOSTIC PERFORMANCE OF PLASMA NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IN DETECTING ACUTE KIDNEY INJURY (AKI) IN ADULT CRITICALLY ILL PATIENTS COMPARED WITH CREATININE IN BLOOD
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 4
Abstract
Background: Acute Kidney Injury (AKI) is prevalent among critical illnesses and related with over 50% death. In current practice the detection of AKI is based on elevation of creatinine ≥ 50% from the baseline (RIFLE/AKIN criteria). Although creatinine in blood is influenced by factors as age and muscles mass. Thus new biomarker was reported to identify AKI in critical ill patients in order to prevent AKI and reduce the mortality by AKI. This was neutrophil gelatinase-assossiated lipocalin (NGAL). Aim: To assess the diagnostic performance of plasma NGAL (pNGAL) in detecting AKI in adult critically ill patients without AKI at the Intensive Care Unit (ICU) entry compared with creatinine in blood (serum or plasma). Method: Electronic search through Glasgow Caledonian University (GCU) used AMED, CINHAL and Medline databases (EBSCO). The used keywords were: (Critical ill patients or critical illness or critical care) and (NGAL or neutrophil gelatinas-associated lipocalin). The scanning for eligibility was initially throughout the title then reading the abstract to select the articles that met the inclusion criteria. Finally, the studies were assessed for the quality by using Scottish Intercollegiate Guidelines (SIGN) diagnosis checklist. Results: The final search's results were thirty two articles. Eight out of 32 articles were scanned for eligibility. Only six articles were included. The significant diagnostic performance of pNGAL compared with creatinine in blood in each study was: Constantin et al (2010) P = 0.956; Cruz et al (2010) P = 0.0001; De Geus et al (2011) P ˂ 0.001; Kokkoris et al (2012) P = 0.001; Aydogdu et al (2013) P = 0.44 and Pickring & Endre (2013) P = 0.06. Conclusion: pNGAL is a good test to diagnose AKI. Despite that, large multicentre studies are recommended to generalize the findings.
Authors and Affiliations
Amina Ali Musallam AL-Amri
Keywords
Related Articles
- EP ID EP672950
- DOI -
- Views 140
- Downloads 0
A CASE OF SYSTEMIC HYPEREOSINOPHILIA ASSOCIATED WITH DOXYCYCLINE USE
Hypereosinophilic syndromes have been attributed to certain drugs in the literature, including minocycline. These syndromes may be restricted to a single organ or may involve multiple systems. We report the case of a 22-...
EFFECTIVENESS OF IMMUNO-CORRECTING THERAPY IN CHILDREN IN THE COMPLEX TREATMENT OF CHRONIC BRONCHITIS
Background: The frequency of respiratory diseases remains one of the urgent problems of modern pediatrics, determining the high level of childhood morbidity, infant mortality, and disability in adolescence. Objective: We...
MODERN LIFESTYLE A RISK AND PREDISPOSING FACTOR OF MUSCULOSKELETAL DISORDERS
Ayurveda has a holistic approach towards lifestyle disorders and there are many diseases which are caused due to management of lifestyle. The burden of these lifestyle disorders is increasing day by day in the society. T...
PROCESS CONTROL AND MEDIUM FORMULATION FOR INDUSTRIAL FERMENTATION
Fermenter control and media formulation has been a dynamic area of research and it captivated the attention of world. All this is because of the new advances in other interrelated areas which may be utilized to overcome...
SUSCEPTIBILITY OF SALMONELLA SPECIES ISOLATED FROM PATIENTS’ STOOL TO COMMONLY USED ANTIBIOTICS
Background: Salmonella infection among humans is an important public health challenge. While commonly available antibiotics are regularly used for its treatment, a changing antibiotics susceptibility pattern has been obs...