The Difference Platelet Lymphocyte Ratio and Thrombocyte Volume between Benign Compared to Carcinoma Thyroid Gland
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 19, Issue 2
Abstract
Background: The inflammatory response is triggered by circulating cytokines, chemokines, which are released by malignant cells in blood circulation, cause systematic alterations such as neutrophilia, thrombocytosis and lymphocytopenia. Objective: To determine the difference thrombocyte/lymphocyte ratio and thrombocyte volume between thyroid nodule and carcinoma. Methods: This research was a case-control study at Dr. Sardjito General Hospital, Yogyakarta, between early January 2015 until the end 2017. The inclusion criteria case group was thyroid carcinoma based on AJCC 2012, while the control group was benign thyroid nodule, underwent thyroidectomy. The exclusion criteria case and control groups were: 1) patients suffering from thyroid hormone disorders requiring therapy before thyroidectomy, 2) patients receiving thyroid suppression therapy prior to thyroidectomy. Pathological anatomy, thrombocyte-lymphocyte ratio and mean thrombocyte volume were examined before thyroidectomy. The sample size each group was 36 samples. Results: Female were more dominant than men patients. There were 63 (87.5%) thyroid nodule and 31 (49.2%) thyroid carcinoma. In thyroid carcinoma, 20 (55.5%) patients were dominant in 45 compared less 45 than years old. Papillary thyroid carcinoma found in 32 (88.9%) patients. In the thyroid nodule the platelet-lymphocyte ratio was 56.72 until 206.79 and platelet volume was 7.5/mL until 11.5/mL, while in thyroid carcinoma between 100.31 until 211.88 and 9.4 until 13.4/mL respectively. Conclusion: It can be concluded that in the thyroid nodule the mean plateletlymphocyte ratio was 122.252 and the mean platelet volume was 10.042/mL, while in the thyroid carcinoma was 145.514 and 10.525/mL respectively. This difference is statistically significant.Among adults, thyroid nodules occur in 19-67%, while the incidence is higher in women and the elderly, but only 5-15% are in the form of thyroid cancer [1]. Thyroid nodules are a common condition and their clinical importance is to distinguish malignancy (4.0-6.5% of all thyroid nodules), evaluate the functional status of the nodule and whether it creates suppression symptoms [2]. Fine Needle Aspiration (FNA) is an early diagnostic tool in thyroid cancer screening and helps to avoid unnecessary surgery. FNA has good sensitivity and specificity for thyroid cancer, with 84% - 93% for sensitivity and 75% - 99% for specificity. There are around 15% -30% of FNA results that are uncertain. Since a biopsy cannot be performed on the thyroid nodule to determine a malignancy, another modality of examination is needed [3].
Authors and Affiliations
Bambang Udji Djoko Rianto, Rangga Putra Nugraha, Sagung R Indrasari, Anggoro Eka Raditya
Keywords
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- EP ID EP620614
- DOI 10.26717/BJSTR.2019.19.003261
- Views 178
- Downloads 0
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