THE EFFECT OF A POLYVINYL ALCOHOL AND DEXTRANE ON THE PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2011, Vol 0, Issue
Abstract
Gels containing lactic acid complexed with chitosan at a stoichiometric ratio 1:1 and 2:1 and 5 - 25% content of polyoxyethylene glycol 200 reveal pH from 2.5 to 4.6. The addition of 20 – 25% poloxamer 407 increases the pH to 4.55 to 5.30 for 1:1 gels and 4.00 to 4.85 for 2:1 gels. The addition of 0.5% polyvinyl alcohol decreases the pH of the investigated gels to 4.00 to 4.55 for 1:1 gels and 3.85 to 4.40 for 2:1 gels. The addition of 1.0% dextrane decreases the pH of investigated gels to 4.40 to 4.90 (1:1) and 4.00 to 4.48 (2:1). Rheological investigations revealed an increase in the dynamic viscosity of preparations containing poloxamer 407 with the addition of polyvinyl alcohol or dextrane in comparison to the reference gels. Results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
Keywords
Related Articles
- EP ID EP73659
- DOI -
- Views 81
- Downloads 0
EFFECT OF IONIC CROSSLINKING ON DENSITY OF HYDROGEL CHITOSAN MEMBRANES
Ionically crosslinked chitosan membranes were prepared and their density was determined using modified pycnometer method. High‑molecular compound: sodium alginate (NaAlg) and low‑molecular compounds: pentasodium tripolyp...
THE INFLUENCE OF C18-FATTY ACIDS ON CHEMICAL STRUCTURE OF CHITOSAN DERIVATIVES AND THEIR THERMAL PROPERTIES
Chitosan derivatives with a series of fatty acids (FA) have been developed using simultaneous N- and O-acylation reaction by the combination of two ways of conducting the reaction, i.e. a carbodiimide catalysis and ionic...
A COMPARISON OF SORPTION EFFICIENCY OF BASIC VIOLET 10 ONTO CHITOSAN AND FLY ASHES AND SAWDUST IMMOBILIZED ONTO CHITOSAN
The course of adsorption curves and calculated values of adsorption capacity point to diversified efficiency of Basic Violet 10 removal depending on the type of sorbent. Data obtained indicate that immobilization of sawd...
MECHANISM OF WATER DIFFUSION INTO NONCROSSLINKED AND IONICALLY CROSSLINKED CHITOSAN MEMBRANES
Ionically crosslinked chitosan membranes were prepared and their swelling behaviour was analysed. Low‑molecular pentasodium tripolyphosphate (TPP) and/or high‑molecular sodium alginate (NaAlg) were used as ionic crosslin...
BIOPOLYMER COMPOSITES BASED ON LIGNIN AND MICROCRYSTALLINE CHITOSAN
The article presents method of extracting lignin from hardwood and softwood after chemical treatment. Lignin fractions were extracted from black liquid (the by-product of pulp and paper industry), in a different reaction...