The effect of Amirkabiria odoratissima M extract on gastric acid and pepsin secretion level in rat<br /> <br />
Journal Title: مجله دانشگاه علوم پزشکی شهرکرد - Year 2007, Vol 8, Issue 4
Abstract
Background and aim: Amirkabiria odoratissima is widely used as an odorant in east south provinces. Many people believe that this plant is useful in treatment of some gastrointestinal disorders. Therefore, this study was conducted to investigate the effect of the plant extract on the secretion rate of acid and pepsin in the stomach of the rats studied. Methods: This is an experimental study involving 3 groups of rats, 8 in each group. The control group received placebo and case groups were received 100 mg/kg and 16.2 mg/kg of Amirkabiria odoratissima by gastrodeodenostomy canola. After anesthesia with nesdonal, 50 mg/kg IP, rats were gone under surgical process, tracheotomy. Subsequently, stomach secretion obtained using Wash Out method included in the first and the second base and measured acid by titrimetry method and pepsin by Anson method. Data were analyzed using t and ANOVA methods. Results: The amount of acid significantly decreased in both Amirkabiria odoratissima groups compared to control group (p0.05). Conclusion: Using of Amirkabiria odoratissima decreases gastric acid secretion and may be useful in patients with gastro intestinal disorders.
Authors and Affiliations
mehtdad Shahrani, mahmoud Rafieian , aliasghar Pilevarian, hedayatollah Shirazde , morteza Hashemzadeh, hosain Yosofi, mohamadtaghy Moradi, azam Ebrahimzadeh, ali Hasanpoor, mehraban Sadeghi, reza Imani, forouzan Ganji , jafar Moghadas
Keywords
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