THE EFFECT OF ANTIEPILEPTIC DRUGS ADMINISTERED IN PREGNANCY ON MICRONUCLEUS FREQUENCY IN CORD BLOOD LYMPHOCYTES
Journal Title: International Journal of Occupational Medicine and Environmental Health - Year 2008, Vol 21, Issue 1
Abstract
[b]Objectives[/b]: Epidemiological data indicate that the pregnancies of epileptic women constitute about 1% of all pregnancies. A large group of antiepileptic drugs (AEDs) applied in long-term monotherapy or polytherapy produce toxic metabolites as well as free radicals and reactive oxygen species. The aim of this study was to assess the potential genotoxic effect of AED therapy in pregnancy on DNA structure of umbilical cord blood lymphocytes. [b]Material and Methods:[/b] The study group were 30 newborns (14 males and 16 females) of mothers receiving long-term AED therapy during pregnancy. The AED considered were carbamazepine, valproic acid, phenyltriazine, benzodiazepine, gamma-aminobutyric acid and sulfonamide analogues. The controls were infants born to mothers not exposed to any medication in pregnancy (n = 20). Positive controls were the same infants, but in this case Nitrogranulogen (Sigma) was added to the collected cord blood samples (n = 11). Micronucleus (MN) assay was used as an indicator of chromosome damage. The frequency (%) of MN/1000 binucleated cells and the nuclear division index (NDI) were calculated. [b]Results:[/b] Mean MN frequency and NDI were respectively 0.110 (±0.152), 1.592 (±0.206) in the study group and 0.050 (±0.061), 1.628 (±0.178) in the controls (statistically non-signifi cant difference, p > 0.1). [b]Conclusion:[/b] The fi ndings did not reveal any genotoxic effect or inhibition of nuclear division in cord blood lymphocytes by AED metabolites. This was refl ected by the absence of signifi cant between-group differences in the mean MN frequency and NDI.
Authors and Affiliations
MONIKA WITCZAK, TOMASZ FERENC, DOBROSŁAWA ŁOPACZYŃSKA, DOROTA NOWAKOWSKA, JAN WILCZYŃSKI, IWONA KOCISZEWSKA
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- DOI 10.2478/v10001-008-0004-1
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