The Effect of Atorvastatin on Oxidative Stress and Renal Function in Experimental Model of Diabetic Nephropathy
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2015, Vol 9, Issue 11
Abstract
Background and Objectives: Atorvastatin has multiple effects independent of lipid lowering, such as anti-inflammatory and antioxidant. The present study was performed with the purpose of determining the effect of atorvastatin on renal function and oxidative stress response in experimental model of diabetic nephropathy. Methods: In an experimental study, male Wistar rats were randomly divided into four groups (N=24): normal, normal treatment, diabetic, diabetic treatment. The rats were made diabetic by an intravenous injection of streptozotocin (40mg/kg) and the treated rats received atorvastatin for 8 weeks (at dose of 40mg/kg/day). At the end of the experiment, blood samples were collected to measure glucose and creatinine levels. The concentration of malondialdehyde (MDA) and the activity of renal catalase were assessed. Results: Chronic uncontrolled hyperglycemia (blood glucose>500mg/dl) significantly increased the blood creatinine in diabetic group (1.70±0.30mg/dl) compared to normal animals (0.40±0.07mg/dl), (p<0.05). Also, hyperglycemia caused a decrease in the activity of catalase enzyme (57%) along with an increase in the MDA concentration (0.15±0.02nmol/mg protein) compared to normal group (0.04±0.02nmol/mg protein). Atorvastatin significantly decreased the blood creatinine of diabetic animals (0.70±0.20mg/dl) compared to normal group (p<0.05). Finally, in the treated diabetic animals, renal activity of catalase enzyme increased (52%) and MDA concentration decreased (0.03±0.01nmol/mg protein). Conclusion: The findings of this study indicated that atorvastatin is able to strengthen the renal antioxidant system during diabetic nephropathy. Therefore, it appears that atorvastatin prevents hyperglycemia-induced nephropathy through the inhibition of free radical production.
Authors and Affiliations
Nastaran Faghihi, Mohammad Taghi Mohammadi, Akram Eidi
Keywords
Related Articles
- EP ID EP479039
- DOI -
- Views 37
- Downloads 0
Assessment of Reaction Time in Congruent and Incongruent Dual Task Stroop Effect in the Elderly
Background and Objectives: In the psychological refractory period, two stimuli with close asynchronous onset are set and two quick responses are required, which the response to the second stimulus is delayed in these con...
The Effect of Education on Empowerment of Girls for the Prevention of Osteoporosis: A Randomized Clinical Trial
Background and Objectives: Osteoporosis is one of the disasters of the recent century. Given the greater involvement of women in all age groups, prevention of osteoporosis is essential in women. Individual empowerment is...
ارزیابی سطح تعارض کار - خانواده درک‌شده در کارکنان بیمارستان شهید صدوقی یزد
زمینه و هدف: تعارض کار و خانواده، پیامدهای منفی زیادی همچون غیبت از کار، افزایش جابه‌جایی شغلی و کاهش عملکرد را در پی دارد. ایـن مطالعـه با هدف بررسی و مقایسه میزان تعارض کار -خانواده درک‌شده در بین کارکنان بخش‌های بالی...
The Relationship of Dietary Glycemic Index and Glycemic Load with Irritable Bowel Syndrome
Background and Objectives: Irritable bowel syndrome (IBS) is a chronic intestinal disorder, which is characterized by irritating pain during defecation or alteration of the bowel habits. In the curent study, the associat...
A Case Report of Tinea Capitis (Endothrix Type) in A 3 Year Old Boy Referred to Laboratory of Ali Ebne Abitaleb Hospital in Qom City (Iran)
Background and Objectives: Endothrix type of tinea capitis is one of the variety of dermatophytic infections of hair and scalp, which is more prevalent in boys, especially the age group of 6-11 years. The important point...