The Effect of Binahong Leaf (Anredera cordifolia [Ten] Steenis) Extract and Bay Leaf (Eugenia polyantha Wight) Extract Compound on Blood Glucose Level of Male Mice (Rattus novergicus L)
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 11
Abstract
Abstract: The aim of this study is to explain the effect of Binahong leaf (Anredera cordifolia [Ten] Streenis) extract and Bay Leaf (Eugenia polyantha Wight) extract compound on glucose level of male mice (Rattus novergicus L.) blood. The mice were divided into eight groups. The normal control group was not induced by alloxan and was not administered by Carboxy Methyl Cellulose (CMC) solution. The other groups were induced by alloxan 100 mg/kg BW in intraperitonial manners and administered by CMC (negative control group); glibenclamide (positive control group); 250 mg/kg BW Binahong leaf extract (Binahong treatment group); 750 mg/kg BW bay leaf extract (Bay Leaf treatment group); 1000 mg/ kg BW compound extract (treatment extract group 1); 500 mg/kg BW (treatment extract group 2); and 250 mg/kg BW compound extract (treatment extract group 3). The administering of experimentation substances was carried out for 21 consecutive days. The result of Kruskal-Wallis and single factor ANAVA (P<0.05)indicates that the three doses of compound significantly reduce the average glucose level on mice blood. The highest result was found on 1000 mg/kg BW dose with the normal glucose content 121.36 mg/dl on the 15thday and 85.37 mg/dl at the 22ndday. Keywords:Alloxan, Anredera cordifolia [Ten] Streenis, Eugenia polyantha Wight, Blood glucose content, Rattus novergicus L.
Authors and Affiliations
Diah Titik Mutiarawati
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