The Effect of Eight Weeks Aerobic Exercise on the Atherogenic Ratio and ABCG8 Gene Expression in PBMC Globules of Overweight Women
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2017, Vol 9, Issue 3
Abstract
Objective: Atherosclerosis of coronary arteries is the most significant cause of disability and mortality worldwide and the most efficient physiological process reducing the risk of this disease is RCT. ABCG8 plays a crucial role in the reverse transfer of cholesterol from macrophages to the liver. The aim of this study is to study the effect of eight weeks aerobic exercise on the atherogenic ratio and the ABCG8 gene expression in peripheral blood mononuclear cells globules in women with overweight. Materials and Methods: The statistical populations were overweight women in Mashhad who were referred to gyms. Among the eligible population, 30 women were included and divided randomly into two groups of exercise and control. Aerobic exercise sessions were three times a week. A blood sample was taken from all cases 48 hours before the first exercise session and 24 hours after the last exercise session. After the separation of mononuclear blood globules, the gene expression was studied via RT-PCR and the atherogenic ratio was measured by special kits. Results: The data demonstrated that exercise has a significant effect on the increase of ABCG8 gene expression in PBMC globules (P-value:0.001, t=5.40), and on the decrease of atherogenic ratio (P-value:0.01, t=-2.86). Conclusion: Based on the findings of the present study, eight weeks of aerobic exercise could lead to an increase in ABCG8 gene in overweight women and improve the function of reverse cholesterol transportation.
Authors and Affiliations
Zahra Ramezani, Seyed Mahmood Hejazi, Amir Rashidlamir
Keywords
Related Articles
- EP ID EP636094
- DOI -
- Views 81
- Downloads 0
Bulimia in Diabetic Patients: A Review on Diabulimia
Objective: Eating disorder (bulimia) is common in young diabetic patients which may influence insulin levels. To reduce calories by manipulating insulin is known as Diabulimia. The purpose of this paper is to define Diab...
Comparative Effect of Two Different Doses of Vitamin D on Diabetic Foot Ulcer and Inflammatory Indices among the Type 2 Diabetic Patients: a Randomized Clinical Trial
Objective: The current study was conducted to compare the effect of 150,000 and 300,000 IU of vitamin D on the healing status of diabetic foot ulcer among the patients with diabetes. Materials and Methods: This randomize...
The Comparison of Quality of Life and Hope in Obese Women with and without Diet Therapy
Objective: The treatment of obesity besides weight loss will have numerous psychological effects. The obese patients have different body image, poor hope and quality of life that influence the process of their treatment....
The Effect of a Combination of Swim Training and Magnesium Supplementation on Thermal Hyperalgesia in Diabetic Rats
Objective: A question raised here as to whether exercise training combined with Mg supplementation could improve the symptoms of neuropathic pain such as the thermal hyperalgesia more effectively than either of the two a...
New Insight into the Relation between Adiponectin and Diabetes
Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecu...