The Effect of Eight Weeks Aerobic Exercise on the Atherogenic Ratio and ABCG8 Gene Expression in PBMC Globules of Overweight Women

Journal Title: Iranian Journal of Diabetes and Obesity - Year 2017, Vol 9, Issue 3

Abstract

Objective: Atherosclerosis of coronary arteries is the most significant cause of disability and mortality worldwide and the most efficient physiological process reducing the risk of this disease is RCT. ABCG8 plays a crucial role in the reverse transfer of cholesterol from macrophages to the liver. The aim of this study is to study the effect of eight weeks aerobic exercise on the atherogenic ratio and the ABCG8 gene expression in peripheral blood mononuclear cells globules in women with overweight. Materials and Methods: The statistical populations were overweight women in Mashhad who were referred to gyms. Among the eligible population, 30 women were included and divided randomly into two groups of exercise and control. Aerobic exercise sessions were three times a week. A blood sample was taken from all cases 48 hours before the first exercise session and 24 hours after the last exercise session. After the separation of mononuclear blood globules, the gene expression was studied via RT-PCR and the atherogenic ratio was measured by special kits. Results: The data demonstrated that exercise has a significant effect on the increase of ABCG8 gene expression in PBMC globules (P-value:0.001, t=5.40), and on the decrease of atherogenic ratio (P-value:0.01, t=-2.86). Conclusion: Based on the findings of the present study, eight weeks of aerobic exercise could lead to an increase in ABCG8 gene in overweight women and improve the function of reverse cholesterol transportation.

Authors and Affiliations

Zahra Ramezani, Seyed Mahmood Hejazi, Amir Rashidlamir

Keywords

Related Articles

The Effect of Purslane Seeds on Fasting Blood Glucose and Serum Liver Enzymes in Patients with Nonalcoholic Fatty Livers

Objective: Nonalcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease in the world and it is one of the liver transplantation causes. The present study aimed to investigate the effect of Purslane s...

Distribution of ABO and Rh Blood Groups among Diabetes Type 2 Patients in Yazd Diabetes Research Center (2015-2016)

Objective: Blood group as a genetic trail can be associated with type 2 diabetes. The aim of this research was to determine the distribution of ABO frequency and RH blood groups in type 2 diabetic patients referred to Ya...

The Combined Effect of Aerobic Activity and Ginger Supplementation on Blood Glucose and Lipid Profile in Overweight Girls

Objective: The purpose of this study was to investigate the combined effect of aerobic activity and ginger supplementation on blood glucose and cardiovascular risk factors in overweight girls. Materials and Methods: In t...

Interval Training Intensity and the Expression of Caspase-9 in Obese Rats with Myocardial Infarction

Objective: Physical exercise reduces myocardial apoptosis but its molecular process is unclear yet. The activated Caspase-9 has a key role in advancing the process of apoptosis. The aim of this study was to evaluate the...

Bulimia in Diabetic Patients: A Review on Diabulimia

Objective: Eating disorder (bulimia) is common in young diabetic patients which may influence insulin levels. To reduce calories by manipulating insulin is known as Diabulimia. The purpose of this paper is to define Diab...

Download PDF file
  • EP ID EP636094
  • DOI -
  • Views 79
  • Downloads 0

How To Cite

Zahra Ramezani, Seyed Mahmood Hejazi, Amir Rashidlamir (2017). The Effect of Eight Weeks Aerobic Exercise on the Atherogenic Ratio and ABCG8 Gene Expression in PBMC Globules of Overweight Women. Iranian Journal of Diabetes and Obesity, 9(3), 95-100. https://europub.co.uk/articles/-A-636094