The effect of excipients on captopril release from preparations disintegrating in the oral cavity (ODT)
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
Captopril is often used to treat hypertension in newborns, infants and the elderly. Orodispersible tablets (ODT) may be a beneficial solution when given to this group of patients. For this purpose, tablets were made and the influence of excipients on the disintegration of tablets and the release of captopril from them was examined. The tablets were obtained by direct compression. The disintegration time was tested in water.The dissolution test was carried out in a paddle apparatus in 0.1 M HCl solution. The captopril content was determined by spectrophotometric method.In order to evaluate the process of disintegration and release of captopril, crospovidone was used in concentrations of 5% and 10%, as a superdisintegrant and mannitol, sorbitol and hypromellose as filling substances, and Avicel in a concentration of 20% and 40% as a filler and disintegrant.The optimized tablets, containing hypromellose (11.36%), glucose (11.36%), Avicel (40%) and crospovidone (5%), showed suitable disintegration time (14 s). An appropriate and complete dissolution profile within 2 minutes was also achieved for this formulation. A correlation was also observed between the disintegration time and the captopril release rate.
Authors and Affiliations
Wioletta Siemiradzka, Barbara Dolińska, Florian Ryszka
Keywords
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- EP ID EP444256
- DOI 10.9790/3008-1401020815.
- Views 68
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