Design and Evaluation of Regioselective Drug Delivery System By Using Dipyridamole Deug As Model
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
In the present research work the gastro retentive floating matrix formulation of Dipyridamole by using various hydrophilic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various natural polymers. The formulation blend was subjected to various preformulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared by using Xanthum gum were unable to produce desired drug release, they were unable to retard drug release up to 12 hours. The formulations prepared with HPMC K15 M retarded the drug release up to 12 hours in the concentration of 200 mg (F8).The formulations prepared with Guar gum were also retarded the drug release for more than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation F8 followed Zero mechanism of drug release.
Authors and Affiliations
Faheem Unnisa Begum, Maimona Farheen, Asfia Kauser,, Ayesha Haseena, Sumaiya Sultana, Zehra Afreen, Zeenath Anjum
Keywords
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- EP ID EP388400
- DOI 10.9790/3008-1202020107
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