The effect of high-intensity Interval training and L-arginine supplementation on serum level of Irisin and body fat percentage in overweight and obese men: A Randomized Clinicai Trial
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2017, Vol 11, Issue 9
Abstract
Background and Objectives: Irisin, as a myokine, has been known in reducing obesity and converting white to brown adipose tissue. The purpose of this study was to investigate the effect of high-intensity interval training and L-arginine supplementation on serum level of Irisin and body fat percentage in overweight and obese men. Methods: In this randomized clinical trial, 40 young healthy overweight and obese men (mean age, 24.5±6.5 years and body mass index, 29.4± 3.6kg/m2), were randomly assigned to 4 groups of high-intensity interval training, L-arginine supplementation, high-intensity interval training+L-arginine supplementation, and placebo. The training program consisted of 3 sessions/week high-speed interval running for 6 weeks. L-arginine supplement was consumed orally 6gr/day. Blood sampling and measurement of body fat percentage, was performed 24 hours before and 48 hours after training program and supplementation. Data were analyzed using ANCOVA and post-hoc Bonferroni tests (p<0.05). Results: The serum level of irisin significantly increased following 6 weeks of high-intensity interval training and high-intensity interval training+L-arginine supplementation (pvalues= 0.017 and 0.019, respectively). While L-arginine consumption did not cause any significant changes in the level of irisin (p=0.19). Body fat percentage had no significant changes following 6 weeks of high-intensity training and L-arginine consumption (p>0.05). Conclusion: According to the findings of this study, 6 weeks of high-intensity interval training and high-intensity interval training accompanied by L-arginine supplementation can be an effective step in facilitating the activation of brown adipose tissue through increasing the serum level of irisin. Thus, high-intensity interval training can be used as a method in the treatment of obesity.
Authors and Affiliations
Sadegh Sadegh, Marziyeh Marziyeh, Mehdi Mehdi
Keywords
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