The effect of hydro-alcohol extract of Trigonella foenum- graceum L. on reproductive system in Balb/c
Journal Title: Journal of Herbal Drugs - Year 2012, Vol 2, Issue 4
Abstract
Background & Aim: Fenugreek (Trigonella foenum- graceum L.) is a medicinal and edible plant in the family Fabaceae. The aim of this study was the effect of hydro-alcohol extract of fenugreek seed on reproductive system of female Balb/c mice. Experimental: The animals divided to five groups of ten members: control group, placebo and three experimental groups. At first all animals synchronized. The control group received no drugs, while placebo group received physiologic serum. The three experimental groups received i.p injection of 50, 100 and 200 mg/kg/2days extract for 20 days. After 10 injections, blood samples were taken from all groups, hormonal measurement, including FSH, LH, progesterone and estradiol were performed by RIA technique. The results are analyzed to use of analysis of unilaterally variance and Duncan’s test by SPSS version11.5 program. Then these groups compared with control group. Ovaries were sectioned and observed by light microscope. Results & Discussion: The data presented in this study showed significant decrease in the level of LH and FSH, also significant increase the level of estradiol in the whole experimental groups, while the level of progesterone only increased in the experimental groups. The results of histological studies of sections showed significant decrease in the folliculogenesis in the three experimental groups. Also significant increase the number of corpus luteum in experimental groups. The degeneration of ovary was observed in experimental group (200 mg/kg/2days extract). Industrial and Practical Recommendations: According to the results of folliculogenesis the ovary tissue in high dosage that indicates anti-fertility effect in female mice.
Authors and Affiliations
Mehrdad Modaresi; Behnaz Mahdian
Keywords
Related Articles
- EP ID EP23369
- DOI -
- Views 383
- Downloads 19
Possible allergic effects and haematological changes induced by oral intake of sumac (Rhus coriaria L.) compared to levamisole in dogs
Background and Aim: Since prior to any research on the drugs, it should be aware of its allergic dose, and considering the importance of hematological system, which reveals the changes in the body, in this study, we deci...
Identification and characterization of chemical composition of Rhus coriaria L. fruit from Hamadan, Western Iran
Background & Aim: Identification, characterization and detection of medicinal plants chemical composition are very important for phytochemical scientific source. Sumac is one of the medicinal plants in the world that u...
A review on application of plant essential oils in food packaging films
Introduction: Active packaging is one of the innovations in food packaging industry that would be a respons to the changing needs of consumers and markets. In this technique, materials such as adsorbents oxygen, moisture...
Effect of ellagic acid on thiol levels in different brain tissue in an animal model of Parkinson's disease
Background & Aim: Parkinson's disease (PD) can be created with loss of dopaminergic substantial nigra neurons which is widely associated with oxidative stress and reduced glutathione (GSH), as the most important and abun...
Phytochemical of essential oil of Stachys lavandulifolia Vahl. collected from a natural habitat in western Isfahan, Iran
Background & Aim: The Lamiaceae family is one of the largest and most distinctive families of flowering plants, with about 220 genera and almost 4000 species worldwide. The genus Stachys is one of the largest represen...