The effect of Licophar on prevention of oral mucositis caused by chemotherapy in cancer patients
Journal Title: مجله علمي دانشگاه علوم پزشكي كردستان - Year 2017, Vol 22, Issue 90
Abstract
Background and Aim: Oral mucositis is a common and debilitating complication that can occur after administration of certain chemotherapy drugs. Yet, no preventive therapy has been recommended for this complication. This study aimed to determine the effect of licophar on prevention of chemotherapy-induced oral mucositis. Methods and method: This was a double blind RCT which was performed in Sanandaj City and included 40 patients with colon and gastric cancer who had received chemotherapy for the first time between 1390 and 1391. 5-FU (FOLFOX4) was prescribed for the patients. Licophar was given to the intervention group, and control group received placebo. The patients were examined for the presence or absence of oral mucositis. Using SPSS.18 software, data were analyzed by descriptive statistics and Mann-Whitney tests, independent T test and chi square. Results: In our study, 25 patients (62.5%) were male and 15 (37.5%) were female. The mean age of the participants was 53.20 ±8.77 years and the mean duration of treatment was 5.05 ±3.15 months. Oral mucositis was not observed in the intervention group, but 35% of the patients in the control group developed this disorder (p <0.01). There were no statistically significant difference between the two groups in relation to age and gender (p> 0.05). Conclusion: Licophar is effective for prevention of oral mucositis induced by chemotherapy.
Authors and Affiliations
MD B Ghaderi, MD Sh Aghayani, MSc N Daneshkhah, MD N Moghimi
Keywords
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