The Effect of Puguntano Extract (Curanga fel-terraeMerr.) Towards Peroxisome Proliferator Activated Receptor- ϒ (PPAR-ϒ) Levels Intype 2 Diabetes Mellitus Wistar Rat Model
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Type 2 diabetes mellitus (T2DM) is a group of diseases that require continuous treatment with a strategy for decreasing blood sugar levels. Peroxisome Proliferator Activated Receptor- ϒ (PPAR-ϒ) is a receptor that may effect the insulin signaling to enhance the insulin sensitivity.Puguntano is a plant of Sumatera Utara used hereditary as anti diabetic.Our study aimsto investigate the effect of Puguntano extract (Curangafelterrae Merr.) towardsPPAR-ϒ levels inT2DM Wistar rat model. It is an experimental study with posttest-only control group design, was conducted in April to August 2018 at Laboratorium Unit PenelitianFakultasKedokteranUniversitasPadjadjaran, Bandung. The samples wereT2DM Wistar rat model was divided into 2 groups: control group and experiment group. Experiment group was given puguntano extract(200mg/Kg). Changes that occurred were assessed using Wilcoxon test with p value of <0.05 was considered statistically significant.This study did for 48 T2DMWistar rat model divided into 2 groups: control group and experiment group. The average PPAR-ϒ levels of the control group was 29,78 (27,71-31,16)ng/ ml while the experiment group was 37,53 (32,35-54,69)ng / ml. There were significant differences in PPAR-ϒ levels between control and experiment groups in T2DMWistar rat model (p<0.001).There were significant increasing in PPAR-ϒ levels in T2DMWistar rat model without and with givePuguntano extract therefore it can be considered in management T2DM, advance study is needed for that achievement.
Authors and Affiliations
Risnahayati Siregar, Santi Syafril, Dharma Lindarto
Keywords
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- EP ID EP395476
- DOI 10.9790/0853-1709105156.
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