THE EFFECT OF SOME BIOCHEMICAL PARAMETERS AND SOME MINERAL SUBSTANCES IN RATS WITH DIFFERENT DOSES OF ELLAGIC ACID
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 1
Abstract
Background: The present study was conducted for the purpose of determining the dose of Ellagic Acid with which it may show its effects on some biochemical parameters and in some mineral substances. Materials and Methods: For this purpose, 40 male rats (Wistar-albino) that weighted 200-250 g were used in the study. A total of 5 groups of rats were formed and there were 8 rats in each group; the Control Group, Group 1 (EA 3 mg/kg), Group 2 (EA 10 mg/kg), Group 3 (EA 12 mg/kg), and Group 4 (EA 20 mg/kg). After 8 weeks of oral Ellagic Acid (EA) administration every other day, the measurements of the biochemical parameters in blood samples were made with a modular auto-analyzer device by using a commercial kit. Results: When the mineral substance levels were compared with the Control Group, it was determined that the Glukoz, T.bil., İ.bil., albumin, Mg, Cl, UIBC levels increased in all groups to which EA was administered, and the Ca, Fe, urea, BUN levels decreased. Conclusion: As a result, based on the data obtained in the present study, it may be claimed that Ellagic Acid decreases the absorption of some mineral substances.
Authors and Affiliations
Dr. Leyla Mis
Keywords
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