THE EFFECT OF THE PROLONGED INJECTION OF NALBUPHINE ON THE STRUCTURAL ORGANIZATION OF ANGIOARCHITECTURE OF ORGANS
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2015, Vol 43, Issue 2
Abstract
Aims: To establish peculiarities of structural organization o f angioarchitecture of pancreas, cerebellum, telencephalon, eyeball and skin in the dynamics o f the long-term effect o f Nalbuphine. Materials and methods: The study was carried out on 48 mature white male rats divided into 3 groups. Nalbuphine was intramuscularly injected to the experimental animals during six weeks in doses: 8, 15, 20, 25, 30, 35 mg/kg of body weight. 18 white rats to which saline solution was injected served as the control group. The research materials were presented by specimens o f the white rats ’ cerebellum, telencephalon, eyeball and skin with the injected vascular bed, histological specimens and ultrathin sections o f the organs. The studies were conducted with application ofhistological, electron microscopy, injection and morphometric methods o f investigation. Results: The first signs o f impairment o f angioarchitecture have been detected already after 2 weeks o f injecting Nalbuphine. Pathological changes keep growing throughout the entire subsequent period o f the experiment manifested by obliteration of capillaries, rarefaction of vaculature, tortuosity of the preserved vessels. After 6 weeks o f injecting Nalbuphine microcirculatory bed of the cerebellar cortex, white substance of the telencephalon, eyeball vascular tunic, pancreas and skin appear to be at the stage of decompensation, when the capillary component is ruined, arterioles are sharply twisted, deformed, their lumen uneven, venules dilated and deformed. Conclusion: injection o f Nalbuphine inflicts a considerable damage on the micro- and ultrastructural organization o f the components ofmicrocirculatory bed o f the experimental animals’ organs.
Authors and Affiliations
Lesya MATESHUK-VATSEBA, Uliana Pidvalna, Anna Bekesevych, Aksiniya Zinko, Petro Popyk, Ivan Diskovskyy
Keywords
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