THE EFFECT OF VARIOUS TYPES OF CHITOSAN USED AS DIETARY SUPPLEMENTS ON BIOAVAILABILITY OF CERTAIN H-2 HISTAMINE RECEPTOR INHIBITORS
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2009, Vol 0, Issue
Abstract
The clinical practice of obesity treatment uses many natural macromolecular compounds which assist in slimming. Chitosan is used in the treatment of obesity due to its lipid, cholesterol, fatty acids, triglycerides and bile acids binding capacity. It is indigestible; it dissolves in the acid environment in the stomach, where it binds many water molecules, forming stable adsorptive gel. A molecule of cationic polymer, such as chitosan, is capable of binding acid drugs. The aim of the study was to determine the capability of binding H-2 receptors antagonists by chitosans present in slimming drugs. The phenomenon of H-2 antagonist receptors absorption was investigated by means of a dynamic method on a biopharmaceutical model which imitated the conditions in vitro. The amount of drug absorbed by chitosan was calculated from the difference in concentrations of the investigated drug before and after sorption. The results of measurements of the bounded drug were used to calculate the mean percentage of the absorbed dose. The obtained findings demonstrate that drugs such as Famotidine and Ranitidine are absorbed by chitosans at applied pH ranges, and the binding capability depends on environmental pH, concentration of the applied drug and the kind of chitosan. Mean absorption of drugs by chitosans ranged from 0.866 g to 2.449 g per 1 g of chitosan. The highest absorption was observed at pH above 7.
Authors and Affiliations
Jan Meler, Janusz Pluta
Keywords
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