The Effect of Viral Infections and Allergic Inflammation in Asthmatic Patients on Immunotherapy
Journal Title: Turkish Journal of Immunology - Year 2018, Vol 6, Issue 3
Abstract
Introduction: The prevalence of allergic asthma are increasing, and the clinical outcome and risk factors of immunotherapy in the treatment of allergy have not been well established. Especially, the impact of viral infection on cytokines in allergic inflammation has yet to be established. This study aimed to determine serum IL-3, IL-11 and IgE levels and blood eosinophil and neutrophil counts during a one-year follow up in patients with allergic asthma on immunotherapy and those on anti-asthmatic drugs only, in the presence of influenza-like illness. Materials and Methods: Sixty patients with allergic asthma were included in the prospective and comparative clinical study with randomization into two treatment groups. Each patient in the immunotherapy group was treated with subcutaneous specific immunotherapy. After patient recruitment, the serum IL-3, IL-11 and IgE levels and blood eosinophil and neutrophil counts and the frequency of influenza-like symptoms were recorded during a one-year follow up. Results: A large percentage of patients in the control group had flu symptoms compared to those in the immunotherapy group. The median serum IL-3 and the IL-11 levels were significantly higher in the immunotherapy group of patients compared to the control group. The median serum IgE level was significantly higher in the immunotherapy group of patients compared to the control group during second quarter of follow-up. Conclusion: The presence of influenza-like symptoms during allergen specific immunotherapy did not significantly change IL-3, IL-11 levels, neutrophil and eosinophil counts. Keywords: Allergic asthma, IL-3, IL-11, IgE, eosinophils, neutrophils, immunotherapy
Authors and Affiliations
Luljeta AHMETAJ, Bakir MEHİC, Refet GOJAK, Arber NEZİRİ
Keywords
Related Articles
- EP ID EP450936
- DOI 10.25002/tji.2018.965
- Views 84
- Downloads 0
Molecular characterization of Amandin, an Allergen from Almond (Prunus dulcis) and the Effect of Heat and Enzymatic Treatments on Human IgE and Rabbit IgG Sensitivity to Almond Allergens
Background: Several clinical studies have shown that the allergy to nuts has increased significantly in recent years. Almond allergy is one of the most significant allergies in several countries. For this reason, we were...
Metoklopramide Bağlı Olarak Gelişen Kounis Sendrom: Olgu Sunumu
A Patient Diagnosed with Kounis Syndrome due to the Metoclopramide: A Case Report In this case report, we mentioned that; a 23 years old and 14 week pregnant woman with no history of anaphylactic or allergic reaction an...
Immunomodulatory Effect of Propolis Extract on Granzyme Expression in CD8+ and CD4+CD25+ T Cells
Objective: The purpose of this study was to explore the effect of propolis extract on CD8+ and CD4+CD25+ regulatory T cell populations and granzyme expression in both cell populations, as propolis has been suggested as a...
Interleukin-2 Immunotherapy for Advanced Cancer
Interleukin-2 (IL-2) was the first approved immunotherapy to show efficacy in advanced cancer. 13–20% of patients with metastatic renal cell carcinoma and metastatic melanoma receiving high-dose IL-2 treatment showed obj...
DOCK8 Protein Eksikliğinin Saptanmasında Akan Hücre Ölçerin Tanısal Değeri
Introduction: DOCK8 deficiency is a combined immunodeficiency with severe eczema, food allergy and autoimmunity. Early diagnosis is important for the treatment of patients. In this study, diagnostic value of flow cytomet...