The Effect of Vitamin C Administration on Interleukin-6 in Male Rats of Wistar Strain Infected with Pseudomomonas Aeruginosa Bacteria
Journal Title: International Journal of Multidisciplinary Research and Analysis - Year 2024, Vol 7, Issue 01
Abstract
Pseudomonas aeruginosa is the main pathogen that causes nosocomial infections in hospitals, and can infect open wounds, burns to necrosis pneumonia. Research shows vitamin C contains antioxidants and antimicrobials. To determine the effect of vitamin C administration on reducing interleukin-6 (IL-6) in male rats of wistar strains infected with Pseudomonas aeruginosa bacteria. This study used an experimental research design with a Post Test Only Control Group Design research design. The subjects of the study amounted to 30 wistar rats which were randomly divided into 5 groups. K(-) group of rats without P. aeruginosa infection. K(+) group of rats infected with P. aeruginosa 108 CFU per head without vitamin C. P1, P2 and P3 in P. aeruginosa infection and given vitamin C at doses of 9 mg, 18 mg and 36 mg/mL/day for 7 days. Day 8 examination of IL-6 levels using the ELISA method. The results of IL-6 levels the One Way Anova test showed significant differences between groups (p = 0.028). The decrease in IL-6 levels in the K3 group infected with Pseudomonas aeruginosa bacteria and vitamin C at a dose of 9 mg/ml/ day experienced insignificant differences with the control group (K1), the K4 group given vitamin C at a dose of 18 mg/ml/day and the K5 group given vitamin C at a dose of 36 mg/ml/day.
Authors and Affiliations
Annisa Nurul Hikmah, Chodidjah, Prasasti Sri Utami
Keywords
Related Articles
- EP ID EP726325
- DOI 10.47191/ijmra/v7-i01-01
- Views 68
- Downloads 0
Developing of a Multiple Intelligences-Based Elementary School Learning Kits to Improve Student Character of Social Awareness
This study aims to produce learning tools based on multiple intelligences (interpersonal, intrapersonal and naturalist intelligences) that are appropriate and effective to improve the social awareness character of fifth...
Measuring Company Value with Intervening Profitability Variables in Companies Listed on the Indonesia Stock Exchange's LQ-45 Index for the 2018–2021 Period
This study aims to analyze the effect of company size, capital structure and dividend policy on company value with profitability as an intervening variable in LQ-45 Companies Listed on the Indonesia Stock Exchange for th...
The Effect of Red Ginger Extract on Tnf-α and Malondialdehyde Serum Level
Pseudomonas aeruginosa is the main pathogen causing nosocomial infections in hospitals, also can infect open wounds, combustio and necrotizing pneumonia. Several plant studies show the presence of antioxidants, one of th...
The Impact of Ancient Chinese on Baihua Language
This article analyzes the influence of the ancient classical literary language - the Wenyan communication language on the Baihua language. Lexical and grammatical differences are discussed on both fronts of a language. S...
Spa Therapy as a Way of Improvement of the Quality of Life for People with Muscellaneous Problems
This research focused on the study of the effect of spa therapy on improving the quality of life, in particular in terms of the areas of physical functionality, psychological functionality, as well as sociality, in peopl...