The Effect of Vitamin D Supplementation in Overweight or Obese Type 2 Diabetic Patients with Vitamin D Deficiency and Dyslipidemia
Journal Title: International Journal of Nutrition Sciences - Year 2018, Vol 3, Issue 4
Abstract
Background: Vitamin D supplementation was shown to reduce obesityrelated oxidative stress and inflammation among overweight or obese people as well as improving glycemic control and lipid profile in type 2 diabetic (T2D) patients. This study was conducted to determine the effect of vitamin D supplementation on metabolic biomarkers, oxidative stress and systemic inflammation in overweight or obese T2D patients with vitamin D deficiency and dyslipidemia. Methods: In this randomized, double-blind placebo-controlled clinical trial, 60 individuals with T2D, vitamin D deficiency and BMI greater than 25 kg/m2 were randomly divided in two groups to receive either vitamin D (50000 IU, once a week) or placebo (1000 mg corn oil, once a week) for eight weeks. At the entry and end of study, blood samples were collected to evaluate serum high sensitive C-reactive protein (hs-CRP), fasting blood sugar (FBS), glycated hemoglobin (HbA1c) malondialdehyde (MDA), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglycerides (TG). Results: At the end of the study, serum FBS (P=0.04), TG (P=0.02) and hs-CRP (P=0.02) levels significantly decreased in the vitamin D supplemented group in comparison to the control group. Supplementation with vitamin D was associated with significant improvements in serum 25 –OH vitamin D levels when compared to the control group. Conclusion: This study indicates that eight weeks supplementation of vitamin D may improve lipid, glycemic and inflammatory indices in overweight or obese T2D patients with vitamin D deficiency and dyslipidemia.
Authors and Affiliations
Sahar Shahriari, Mohammad Hassan Eftekhari
Keywords
Related Articles
- EP ID EP448433
- DOI -
- Views 92
- Downloads 0
PCR Detection of Coxiella Burnetii in Bovine Bulk Tank Milk Samples in Shiraz, Southern Iran
Background: Q fever is a zoonosis caused by Coxiella burnetii, an obligate intracellular organism. In Iran, healthy cattle are the main reservoirs of these microorganisms. The consumption of milk and non-pasteurized dair...
Diet Quality of Adolescents in Shiraz, Southern Iran Needs Moderate to Severe Improvement
Background: The importance of healthy eating habits increases in adolescence therefore, healthy eating index (HEI) and diet diversity score (DDS) are embedded in order to evaluate them. This study was undertaken to asses...
Effect of Direct and Indirect Ultrasonic Methods on Microbial Load and Chemical Quality of Raw Wheat Germ
Background: Thermal methods such as pasteurization and sterilization are currently used to eliminate microorganisms, but they may reduce nutrition value or disturb texture, flavor, taste and color. This study assessed th...
The Effects of Papaya Fruit as Anti Diabetes Type 2: A Review
Diabetes mellitus (DM) is a disease that results in an imbalance in the body ability to use food efficiently caused by the pancreas failure to produce insulin or dysfunction of the body to use insulin properly. Type 2 DM...
Microbial and Chemical Properties of Mahyaveh: A Traditional Iranian Fish Sauce in Zarrin Dasht City, Iran
Background: Mahyaveh is a fermented sauce made from fish. This study was conducted to investigate microbial and chemical properties of Mahyaveh in Zarrin Dasht city of Fars province, southern Iran. Methods: Twenty-three...