The Effect of Xylitol on Bone Alkaline Phosphatase Serum Level and Bone Defect Diameter in Rabbits

Journal Title: Journal of Applied Veterinary Sciences - Year 2022, Vol 7, Issue 1

Abstract

Our study aimed to investigate the systemic and topical effect of xylitol on the bone Alkaline Phosphatase and the bone mineral density in rabbits at the healing site in femur bone postoperatively. Twenty-four healthy white male, New Zealand rabbits, will be taken from the same species; the same age, Weight, and circumstance were chosen in this study. The Weight ranges from (1.3- 1.8) Kg and aged (6-8) months were used in this study ). All animals were submitted to operation in the femur bone region. The groove of 2mm diameter was drilled in the femur bone by using the heavy-duty dental engine. After the operation, the rabbits were randomly divided into three groups (8 rabbits/group); each group was subdivided into 2 experimental periods (14,28 days) four rabbits for each period as follows: Control group, n=8 (the hole was not filled by anything), locally treated group n=8 (xylitol powder was applied and condensed well in the hole) and systemically treated group n=8 (the hole was not filled by anything but the rabbits received orally of 1mg/kg of xylitol. Bone alkaline phosphates and radiological analysis were measured after 14 and 28 days, respectively. Statistical analysis showed significant differences between all groups (control and treated). Biochemical analysis for bone alkaline phosphatase showed a significant increase in bone Alkaline Phosphatase in the systemically treated group compared with the control one. The estimated bone healing by measuring the diameter of bone defect showed a highly significant difference in diameter in the bone defect at day 14 between the control group (36.0±0.05) in comparison with the treated local group and systemic treated group (39± 0.78) and (25± 0.90) respectively. Also, we found a significant difference between the local treated group (39± 0.78) and systemic treated group (25± 0.90) in diameter. Still, on day 28, there was no significant difference between the control group (28.0±0.55) and the local treated group in diameter in the bone defects. There were significant differences between the control and the local treated groups compared with the systemic treated group (24.0 ± 0.23) at p ≤0.05. This study concluded that xylitol was accelerating bone healing when used topically and systemically, and this was indicated by increasing the bone alkaline phosphates and bone mineral density in densitometric analysis.

Authors and Affiliations

Ahmed H. Naji, Wael T. Al-Watter and Ghada A. Taqa

Keywords

Related Articles

Preliminary Studies On The Virus Causing Outbreak Of Duckling Short Beak And Dwarfism Syndrome (Sbds) In Egypt

Many Mule, Muscovy, and Bikini duck flocks in different duck-producing regions in Egypt have shown signs of a new disease designated "short beak and dwarfism syndrome" (SBDS) since 2015. The ducks with SBDS showed strong...

Isolation and Antimicrobial Resistance Phenotype of Salmonella species from Ready-to-Eat Roasted Meat (Suya) in Ilorin, Kwara State, Nigeria

Salmonella are pathogenic bacteria that can contaminate food products during or after processing. They are among the most important food borne pathogens worldwide contaminating a wide range of animal products including m...

Immuno-Potentiator Effect Of Rapeseed Or Soybean Oil With Foot And Mouth Disease Vaccine In Calves

One of the effective recommendation for control of Foot and Mouth disease virus is the proper vaccination by a highly potent vaccine. Such a vaccine should be specific to the circulated field serotype of foot and mouth d...

Prophylactic Control Of Mycoplasma Contamination In Starting Biological Materials Used In Viral Vaccine Production

Mycoplasma contamination remains a major concern in the biopharmaceutical industry especially in tissue culture based viral vaccine and its presence and/or its endotoxin-like metabolites in the final products can result...

Polycyclic Aromatic Hydrocarbons in Grilled Meats from Restaurants

Polycyclic aromatic hydrocarbons are a group of lipophilic compounds that can be generated during the preparation of food items at elevated temperatures. They are regarded as potentially genotoxic and carcinogenic to hum...

Download PDF file
  • EP ID EP698579
  • DOI https://dx.doi.org/10.21608/javs.2021.97815.1105
  • Views 93
  • Downloads 0

How To Cite

Ahmed H. Naji, Wael T. Al-Watter and Ghada A. Taqa (2022). The Effect of Xylitol on Bone Alkaline Phosphatase Serum Level and Bone Defect Diameter in Rabbits. Journal of Applied Veterinary Sciences, 7(1), -. https://europub.co.uk/articles/-A-698579