The Effect of Xylitol on Bone Alkaline Phosphatase Serum Level and Bone Defect Diameter in Rabbits
Journal Title: Journal of Applied Veterinary Sciences - Year 2022, Vol 7, Issue 1
Abstract
Our study aimed to investigate the systemic and topical effect of xylitol on the bone Alkaline Phosphatase and the bone mineral density in rabbits at the healing site in femur bone postoperatively. Twenty-four healthy white male, New Zealand rabbits, will be taken from the same species; the same age, Weight, and circumstance were chosen in this study. The Weight ranges from (1.3- 1.8) Kg and aged (6-8) months were used in this study ). All animals were submitted to operation in the femur bone region. The groove of 2mm diameter was drilled in the femur bone by using the heavy-duty dental engine. After the operation, the rabbits were randomly divided into three groups (8 rabbits/group); each group was subdivided into 2 experimental periods (14,28 days) four rabbits for each period as follows: Control group, n=8 (the hole was not filled by anything), locally treated group n=8 (xylitol powder was applied and condensed well in the hole) and systemically treated group n=8 (the hole was not filled by anything but the rabbits received orally of 1mg/kg of xylitol. Bone alkaline phosphates and radiological analysis were measured after 14 and 28 days, respectively. Statistical analysis showed significant differences between all groups (control and treated). Biochemical analysis for bone alkaline phosphatase showed a significant increase in bone Alkaline Phosphatase in the systemically treated group compared with the control one. The estimated bone healing by measuring the diameter of bone defect showed a highly significant difference in diameter in the bone defect at day 14 between the control group (36.0±0.05) in comparison with the treated local group and systemic treated group (39± 0.78) and (25± 0.90) respectively. Also, we found a significant difference between the local treated group (39± 0.78) and systemic treated group (25± 0.90) in diameter. Still, on day 28, there was no significant difference between the control group (28.0±0.55) and the local treated group in diameter in the bone defects. There were significant differences between the control and the local treated groups compared with the systemic treated group (24.0 ± 0.23) at p ≤0.05. This study concluded that xylitol was accelerating bone healing when used topically and systemically, and this was indicated by increasing the bone alkaline phosphates and bone mineral density in densitometric analysis.
Authors and Affiliations
Ahmed H. Naji, Wael T. Al-Watter and Ghada A. Taqa
Keywords
Related Articles
- EP ID EP698579
- DOI https://dx.doi.org/10.21608/javs.2021.97815.1105
- Views 97
- Downloads 0
Efficacy Of Lyophilized Inactivated Rabies Vaccine
An interesting finding that emerged from the study was the difference in potency between inactivated rabies vaccines prepared in liquid and lyophilized forms. Inactivated rabies vaccine prepared from BHK21 infected cell...
Camel Trypanosomiasis “Dhukaan” in Lower Juba Region of Somalia: Importance and Microscopic Survey
Camel trypanosomiasis is the most significant animal disease in the camel zone of Somalia. The Somali camel is also found in the southern areas of Somalia, which have a high density of vectors, including Glossina. The ec...
Detection of Mold and Aflatoxin B1 in Mayonnaise Product from Egyptian Markets by HPLC
Egyptian consumers' demand and preference for sauces like mayonnaise have increased lately. The processing and packaging techniques of such products may safeguard the consumer from bacterial hazards, although mold and/or...
Detection of Aflatoxigenic Fungi in Poultry Feed
Mycotoxins are poisonous biomolecules produced as secondary metabolites by some fungal species, as they grow on various substrates under suitable growth conditions. Approximately, 83% of these deaths occur in East Asia a...
Histopathological and the Dose Depended Effects of Aspartame toxicity on Liver and Kidney of Rats
Aspartame is a commonly employed artificial sweetener used by hyperglycemic patients and in food management. Its danger depends on the outcome of previous studies that revealed controversy. The purpose of this study was...