The effects of cochleostomy of hearing threshold in animal experiment
Journal Title: Otolaryngologia Polska - Year 2010, Vol 64, Issue 7
Abstract
SUMMARY Introduction: To assess an effect of cochleostomy on hearing threshold in guinea pigs. Material and methods: The authors performed animal experiments using fi ve 3-month-old guinea pigs. Before experiment hearing threshold were evaluated. Surgery involved access to the temporal bone by a post-auricular incision. After a wide opening of the bulla cochleostomy was created (10 000 turn/min, diamond bur of 0,8 mm diameter). Hearing threshold was identifi ed on the basis of presence of wave V in auditory brainstem responses (ABR) for click and frequency-specifi c stimulation. Also morphology and latency changes for wave V for this stimulation was assesed. Hearing status was evaluated before, just after and 1-, 2-, and 4-weeks after surgery. For surgical procedure and ABR examination all animals were anesthetized with an intramuscular injection of ketamine (50 mg/kg) mixed with xylazine (9 mg/kg) in the supplemental doses. After surgery the animal was treated by antibioticoterapy for 3 days – Enrofl oksacyna 0,3 ml subcutaneouly and analgesic – Tolfedine 0,05 mg in second day. Results: Four week observation of ABR morphology and hearing thresholds for click and frequency-specifi c stimulation of 100 dB SPL intensity showed only temporary changes confi rming that cochleostomy did not affect cochlear function. Conclusions: The correctly performed cochleostomy in guinea pigs did not affect persistently the cochlear function indicating that such an option of CI electrode insertion in patients is safe.<br/><br/>
Authors and Affiliations
Olimpia Stanisławek-Sut, Krzysztof Morawski, Kazimierz Niemczyk
Keywords
Related Articles
- EP ID EP345861
- DOI -
- Views 107
- Downloads 0
The usefulness of the NBI – narrow band imaging for the larynx assessment
Narrow band imaging (NBI) by enhancing the contrast between the mucosal epithelium and submucosal vessels facilitates diagnosis of precancerous and cancerous lesions, as well as hypertrophic lesions such as laryngeal pap...
Metodologia pomiarów ruchomości elementów ucha środkowego za pomocą laserowej wibrometrii dopplerowskiej
Skojarzone leczenie endowaskularne i chirurgiczne pourazowych krwawień z nosa
We report on two cases of patients, in whom endovascular embolization of the maxillary artery and next surgical ligation of the anterior ethmoidal artery was performed due to posttraumatic intracrable epistaxis. In those...
Giant cystic primary mucoepidermoid carcinoma of mandible: A rare case and literature review
Primary intra-osseou s mucoepide rmoid carcinoma arising from jaw is an extrem ely rare condition accounting to le ss than 2% of all mucoepide rmoid carcinomas. In the jaw, it occurs more commonl y in mandible than maxil...
Kliniczna ocena tomografi i komputerowej nosa i zatok przynosowych
Introduction. Computed tomography is a basic imaging technique in nose and paranasal sinuses disease’s nowadays. Aim. The aim of the study was to outline current methodology of CT scanning of nose and paranasal sinuses....