THE EFFECTS OF MINI-DOSE ASPIRIN ON HEPATIC FUNCTIONS.
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 3
Abstract
Aspirin is the prototype of NSAIDs, that’s widely used as an anti aggregant for prophylaxis of ischemic heart disease (IHD), usually is given as 75 mg/d, aspirin is a non selective COX inhibitor, as well as is the only irreversible inhibitor of COX enzymes. Aspirin is metabolized into acetic acid and salicylates, hence aspirin can cause salicylism, in which signs and symptoms may range from mild nausea, vomiting, abdominal pain, lethargy, tinnitus and dizziness to severe such as seizures or cerebral edema depending on the dose consumed. Although very-low-dose (mini-dose) aspirin is used increasingly as a platelet aggregation inhibitor, no studies have been published on whether aspirin's hepatic effects occur at dosages of <0.5 gm/day. The aim of the present study was to evaluate the effects of commonly used mini-dosages of aspirin on hepatic functions in elderly patients for prophylaxis of IHD. About 54 elderly patients are investigated, they were given 75mg, 150 and 325 mg, for about 5 months, CBC and hepatic tests were taken before and after treatment. The serum of blood glucose is also evaluated. The main result is that hepatic functions in patients receiving 75, or 150 mg /d still around normal ranges, but significant hepatic alterations have occurred in patients treated by 325 mg/d., as well as the incidence of hypoglycemia.
Authors and Affiliations
Dr. Omar Rashid Sadeq
Keywords
Related Articles
- EP ID EP617292
- DOI -
- Views 159
- Downloads 0
HAASE ENZYME AS INDICTER FOR DIAGNOSING THE RHEUMATOID ARTHRITIS (RA) DISEASE FOR HUMAN
In this study, the activity of (HAase) enzyme for (30) serum samples of patients suffering from (RA) were experimentally investigated. Serum samples are gathered from women suffering from RA disease at age range from 20-...
IMPROVEMENT OF GLUCOSE TOLERANCE WITH A POLYHERBAL FORMULATION OF BRASSICA RAPA SUBSP. RAPA ROOTS AND ZINGIBER OFFICINALE RHIZOMES
Background. Brassica rapa subsp. rapa (Brassicaceae family) and Zingiber officinale (Zingiberaceae family) are two plants cultivated in Bangladesh, respectively, for consumption as vegetable and as spice. A number of Bra...
LIPID PROFILE OF MALARIA INFESTED WISTAR ALBINO RATS TREATED WITH THE CRUDE EXTRACT OF ARTEMISIA ANNUA AND ARTEMISININ COMBINATION THERAPY.
The comparative effects of the crude extract of Artemisia annua and artemisinin combination therapy (ACT) on the lipid profile of wistar albino rats was evaluated in this study. Twenty four (24) rats used were divided in...
ANALYSIS OF THE EFFECT OF LEVODOPA ON NITROGENOUS BASES USING QUANTUM METHOD
L-3,4-Dihydroxyphenylalanine (DOPA) or Levodopa (Lev) has been used since the 1960s and has become one of the most widely used drugs in neurology. Lev is a metabolic precursor drug for dopamine. Its therapeutic and harmf...
TO EVALUATE THE EFFICACY OF KUSHTHADI CHURNA AS AVCHURNAN & KUSHTHADI LEPA IN THE MANAGEMENT OF VICHARCHIKA ALONG WITH NAVKASHAYA
Ayurveda is a clinical science and its concepts and principles are moulded in such a way that it becomes useful in clinical parlance. It is the duty of scholar of the Ayurveda to prove these Ayurveda principles in front...