WILSON DISEASE-AN OVERVIEW
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 1
Abstract
Wilson disease is a rare inherited disorder that prevents the body from getting rid of extra copper. Our body needs a small amount of copper from food to stay healthy. Too much copper is poisonous. The condition is due to mutations in the Wilson disease protein (ATP7B) gene. Normally liver releases extra copper into bile. With Wilson disease, the copper builds up in liver and it releases the copper directly into bloodstream. This can cause damage to brain, kidneys and eyes. Wilson disease is present at birth, but symptoms usually start between ages 5 and 35. It first attacks the liver, the central nervous system or both. The most characteristic sign is a rusty brown ring around the cornea of the eye. A physical exam and laboratory tests can diagnose it. Treatment is with drugs to remove the extra copper from body. It needs to take medicine and follow a low-copper diet for the rest of life. WD is treated with medication that reduces copper absorption or removes the excess copper from the body, but occasionally a liver transplant is required. A single abnormal copy of the gene is present in 1 in 100 people, who do not develop any symptoms (they are carriers). If a child inherits the gene from both parents, the child may develop Wilson's disease. Wilson's disease occurs in 1 to 4 per 100,000 people.
Authors and Affiliations
Shaimol T.
Keywords
Related Articles
- EP ID EP617000
- DOI -
- Views 243
- Downloads 0
MACROPHAGES AS A KEY FACTOR IN THE PROCESS OF TUMOUR FROM THE INITIATION TO THE THERAPY OF CANCER.
The tumor environment is a complex ecological system made up of cells and serves as support to the tumor cells from their implantation to the state of malignancy. Among all the cells of immunity (innate and adaptive) mac...
DENDRIMER- A NOVEL TECHNIQUE FOR DRUG DELIVERY
Introduction: Dendrimers are a novel class of synthetic macromolecules having highly branched, three dimensional, nanoscale structures with very low poly dispersity and high functionality. The structure of these material...
IN VITRO DNA DAMAGE INHIBITION ACTIVITY OF AQUEOUS AND ETHYL ACETATE EXTRACT OF VERNONIA AMYGDALINA LEAVES
Vernonia amygdalina (Asteraceae) is a plant widely used both for nutritional and medicinal purposes throughout tropical Africa. Its health-promoting ability might be related to the effect various bioactive components of...
KNOWLEDGE OF DIABETIC PATIENTS ABOUT SYMPTOMS AND SELF-MANAGEMENT OF NON-SEVERE HYPOGLYCEMIA IN SUDANESE PATIENTS
Hypoglycemia is the most common acute complication of diabetes and can limit therapeutic efforts to improve glycemic control. This study aimed to evaluate the diabetic patient's knowledge about the symptoms of mild hypog...
IMPURITY PROFILING: OVERVIEW ON IMPURITY PROFILING AND REPORTING METHODOLOGIES ADOPTED BY UNITED STATES AND EUROPE
Impurities are not acceptable in drug formulation. It is considered as unwanted chemicals or organic material which remains with Active Pharmaceutical Ingredient (API’s). The impurity is produced either during formulatio...