The Effects of Nano-honey Containing Hydroxyapatite on Socket Healing
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 12, Issue 4
Abstract
Background/Purpose: The aim of this study was to evaluate the effect of nano-honey containing calcium compounds on restoration of tooth socket. Material and Methods: Based on the placed substance on tooth socket, the samples were divided into two treated groups including nano-honey, nano-honey with calcium compounds and control group in which receiving no substance. Eight weeks of post-treatment, biopsy was performed and the type of epithelium, the type of connective tissue, the degree of inflammation, and the type of the bone in the alveolar crust were histologically compared between all groups. Results: Histological examination of 9 lamella of tooth sockets has revealed that there was no relationship in soft and hard tissue restoration between both treated group compared to the control group. The epithelial tissue in nano-honey contains calcium compounds group consisted of 33.3% normal epithelium and 66.7% squamous epithelium. The results have shown that both the nano-honey and control groups consisted of 33.3% fibrous and 66.7% granulation tissues. It has been observed that in nano-honey containing calcium compounds group, the inflammation rate was less than 10 in 66.7% of the cases and it was between10-30 in 33.3% of the cases. Examining the bone type in the alveolar crust has illustrated that it was seen that there was no normal bone and resorption in nano-honey containing calcium compounds group. In case of nano-honey and control groups, 33.3%normal bone and66.7% resorption were observed. Conclusion: The findings of the present study have revealed that applying calcium compounds along with nano-honey leads to a better therapeutic effect.Tooth loss is an age-related complication. It is quite pervasive due to extensive caries, gum sickness, injuries and fractures [1]. Tooth removal is an operation bringing about an injury in both the delicate and hard tissues [2]. By removing a tooth, the encompassing alveolar bones experience a progression of ruinous and inflammatory processes [3]; hence its normal recovery is related with critical loss of vertical and horizontal dorsal alveolar bone [4,5]. The lost tooth is replaced in order to restore the proper functioning. Several approaches are currently applied to replace the missing tooth, such as inserting an implant which requires presence of sufficient amount of bone in the desired location [6]. Thus, restoration of tooth socket is necessary to maintain alveolar ridge height and width. Several solutions have been suggested to reduce and minimize osteoporosis and accelerate restoration process of post-tooth removal, including the use of synthetic bone marrow material, autologous connective tissue, a plasma rich in growth factors (PRGF) at the tooth extraction site as well as various drugs and substances [7]. The best approach to maintain and accelerate tooth socket restoration. is application of bone grafting. Nevertheless, due to the difficulties and limitations of this method, more easier and expanded methods are being investigated. Commonly used medicines have various complications and are harmful to humans. Recently, there has been a growing interest in medicines and natural products leading to their use in many areas of dentistry [8]. Application of artificial biomaterials, such as hydroxyapatite, in the restoration of lesions of hard tissue of the bone is one of the main interests of researchers. Hydroxyapatite is widely used due to its high biocompatibility and osteoconductivity properties. Various studies have shown the significant effect of this material on accelerating the repair and increasing bone volume [9,10]. On the other hand, honey is a substance that has been used by men for the treatment of wounds. According to studies, honey has an antimicrobial activity against oral pathogens and draws moisture from the environment and therefore protect the wounds.
Authors and Affiliations
Naghmeh Bahrami
Keywords
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- EP ID EP593776
- DOI 10.26717/BJSTR.2019.12.002280
- Views 144
- Downloads 0
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