The Effects of Paclitaxel on Nerve Conduction Velocity and Motor Unit Action Potential In Spraque-Dawley Rats
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 3
Abstract
This study aimed to investigate the toxic effects of paclitaxel on sensory and motor nerve conduction velocities (SNCV and MNCV) and motor unite action potentials (MUAP) in adult male Spraque-Dawley rats. Rats were divided into two equal groups as the control and paclitaxel group. Control animals were injected with 0.5 ml normal saline, while those in paclitaxel group were given 6 mg/kg paclitaxel in normal saline for three days i.p. On days 4, 7, 10 and 13 of the experiment, animals were weighed, and SNCV-, MNCV- and MUAP-values were determined under sedation with Pentothal sodium. Body weights, MUAP and MUAP duration values were not affected by paclitaxel. The most affected variables were SNCV and MNCV, respectively. SNCV- and MNCV-values determined in paclitaxel-group were 41% and 20% less than those of controls on day 4 (P
Authors and Affiliations
Cengiz ÜNSAL, Muharrem BALKAYA, Hikmet YILMAZ, Aykut ÜNER
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