The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery

Journal Title: International Journal of Medical Science and Public Health - Year 2017, Vol 6, Issue 8

Abstract

Background: Adjuvant play very important role in regional anesthesia and search for better adjuvant is still going on. Objectives: The objectives of this study are to find equipotent doses and to compare the efficacy of two α2 agonists clonidine and dexmedetomidine as an adjuvant in supraclavicular block. Materials and Methods: A total of 90 patients of the American Society of Anaesthesiologists 1 and 11 of age 20-50 years undergoing elective upper limb surgeries under supraclavicular block divided into three groups: Group N: Received injection bupivacaine 0.5% 15 ml + injection. Lignocaine with adrenaline 2% 15 ml + normal saline 0.5 ml. Group D: 1 µg/kg dexmedetomidine. Group C: 1.5 µg/kg clonidine as studied drug in place of normal saline. Onset, duration of sensory and motor block, duration of analgesia, visual analog scale (VAS) score, hemodynamics, sedation, and other side-effects noted down. Results: Onset of sensory and motor block in Group D (8.13 ± 2.52 and 12.13 ± 2.90), Group C (7.97 ± 2.58 and 12.47 ± 2.89), and Group N (12.43 ± 2.57 and 17.97 ± 3.06) groups, respectively. Duration of sensory and motor block was 528.2 ± 105.27 and 464.17 ± 93.15 in Group D, 544.97 ± 113.51 and 476.57 ± 105.41 in Group C, and 292 ± 77.4 and 257 ± 75.63 in Group N, respectively. Duration of analgesia was 644.93 ± 118.45 in Group D and 646.93 ± 112.18 in Group C and 352.6 ± 84.39 in Group N. Both studied groups were comparable to each other in above parameters and are significantly better than Group N. VAS score in the post-operative period at 360 min was higher in Group N (5.12 ± 0.68) when compared to Group C (4.5 ± 0.73) and Group D (2.07 ± 0.94), respectively. Conclusion: Dexmedetomidine and clonidine as an adjuvant to supraclavicular block were found equipotent in the studied doses. However, post-operative VAS was found low in dexmedetomidine group.

Authors and Affiliations

Yogesh Tilkar, Sangeeta Bansal Agarwal, Rahul Gupta, Sanjeevani Karmalkar, Prabha Khatri, Neetu Gupta

Keywords

Related Articles

Knowledge of emergency contraception among women seeking abortion services at tertiary care hospital in Western Maharashtra

Background: A safe, effective, and handy method to prevent unplanned pregnancy is available in the form of emergency contraception (EC). By timely and judicious use of EC, 75–85% of the unplanned pregnancies and thereby...

Evaluation of pulmonary function tests in elderly population

Background: An understanding of age-related changes in the respiratory functions is important. Objective: To evaluate the pulmonary function tests (PFTs) in elderly population and to construct prediction equations for th...

  Feasibility of two staged newborn hearing screening and identification of risk factors for hearing loss other than those included in high risk registry (HRR) given by joint committee on infant hearing (JCIH)

 Background: Hearing impairment in neonates is a hidden disability, which is usually detected around 2 years of age. Crucial speech and language development begins during first six months of life. Undetected hearin...

Langerhans cell histiocytosis involving bilateral temporal bones in infant patient: a case report  

 Langerhans’ cell histiocytosis (LCH) is a rare pediatric disease of unknown etiology. The mastoid and skull base are common sites of involvement in LDH. We present a case of bilateral langerhans histiocytosis in 9...

Download PDF file
  • EP ID EP326490
  • DOI 10.5455/ijmsph.2017.0513713062017
  • Views 78
  • Downloads 0

How To Cite

Yogesh Tilkar, Sangeeta Bansal Agarwal, Rahul Gupta, Sanjeevani Karmalkar, Prabha Khatri, Neetu Gupta (2017). The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery. International Journal of Medical Science and Public Health, 6(8), 1314-1319. https://europub.co.uk/articles/-A-326490