The Efficacy of Nt- Pro Bnp with Reference To LVEF As A Marker of Ventricular Dysfunction in Cardiac Failure.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Heart failure comprises the constellation of clinical symptoms and signs leading to frequent hospitalisation, poor quality of life due to failing heart muscle that cannot pump blood around the body effectively. The early and reliable diagnosis of left ventricular systolic function is done by ECHO to measure Left Ventricular Ejection fraction (LVEF). Due to the cost and limited availability, cost effective tools needs to be found out. The aim of the study is to determine the efficacy of neuro-hormonal markers like NT pro BNP in predicting ventricular systolic dysfunction and its interrelationship with LVEF in heart failure cases. The current case-control study includes 50 numbers of cardiac failure patients and an equal number of age and sex matched controls. The biochemical parameters like fasting plasma glucose, cholesterol, creatine kinase (CK) and CK-MB were increased significantly (p < 0.001) while HDL was decreased significantly (p <0.05) in cases in comparison to control. There was a significant increase of NT-pro BNP in cases compared to controls (p< 0.001).There was an inverse correlation betweenLVEF and NT- pro BNP (r= - 0.64752). A cut off value of 97.9pg/ml gives a specificity of75%, sensitivity of 76%, positive predictive value of 28% and negative predictive value of 97% NT- pro BNP could be helpful in diagnosis of ventricular systolic dysfunction and immediate intervention.
Authors and Affiliations
Dr. Anuva Mishra, Dr. U. K. Das, Sachin Singhi, Prof (Dr) S. Mahapatra
Keywords
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