The efficacy of two different doses of gabapentin (300mg and 600mg) along with NSAID (diclofenac transdermal patch 100mg) in postoperative pain management following abdominal hysterectomy
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 3
Abstract
Context: Gabapentin, an antiepileptic drug has a role in acute postoperative pain management due to its anti hyperalgesic property. Pre-emptive analgesia is the recent concept in multi modal pain management. The purpose was to analyse the effect of Gabapentin as Pre-emptive analgesic.Aim:To study the efficacy and safety of Gabapentin on pain following abdominal hysterectomy and on reduction in Tramadol consumption.Methods and Materials: A randomized, placebo-controlled, double -blind study conducted on 120 ASA I and II patients planned for abdominal hysterectomy. The patients were randomized to receive either oral placebo or Gabapentin 300 mg or Gabapentin 600 mg 1 hour before surgery along with diclofenac transdermal patch 100 mg. Spinal anesthesia was instituted with injection Bupivacaine 0.5% heavy 15mg. Heart Rate, SpO2, Blood pressure, respiratory rate, pain intensity score, rescue analgesic consumption and patient satisfaction score and side effects were recorded. Statistical analysis:Parameters were analysed using one-way ANOVA, Post Hoc LSD test and Chi-Square test. P-value ≤0.05 was considered statistically significant. Results: The pain intensity scores and total Tramadol consumption were significantly reduced in Gabapentin 600 mg group when compared to Gabapentin 300 mg and placebo. The patient satisfaction score was significantly high in Gabapentin 600 mg.Conclusion: Pre-emptive use of Gabapentin (600mg) combined with Diclofenac transdermal patch (100mg) significantly decreases postoperative pain and rescue analgesic requirement, thus provides an effective means of giving postoperative analgesia following abdominal hysterectomy.
Authors and Affiliations
Suresh Rajkumar, V Hari Babu
Keywords
Related Articles
- EP ID EP616928
- DOI -
- Views 166
- Downloads 0
Assessment of recovery from anaesthesia with analgesic doses of ketamine: A randomized controlled study
Background: Delayed recovery or emergence can occur after general anaesthesia and it is one of the major challenges for an anesthesiologist. The time to recovery from anesthesia is affected by patient factors, anesthetic...
A comparative study of Dexmedetomidine versus midazolam with fentanyl for monitored anaesthesia care in tympanoplastyunder local anaesthesia
Background and Aims: Monitored anaesthesia care (MAC) is a procedure in which the local anaesthesia(LA) and sedation provided using different drugs. We conducted this comparative study to see the safety and efficacy of D...
A clinical comparative study between Rocuronium and Suxamethonium for endotracheal intubation
Background: This is a prospective randomized study done to compare the two drugs namely Rocuronium bromide and suxamethonium for tracheal intubation and further to evaluate whether Rocuronium bromide can be an acceptable...
A comparative study between ondansetron, metoclopramide and placebo as a prophylactic medication to reduce postoperative nausea and vomiting
Background: Nausea and Vomiting are commonly faced post operative health illnesses among the patients undergoing surgery under general anesthesia. This study was planned to compare the effect of ondansetron, metocloprami...
Effects of addition of dexmedetomidine to bupivacaine on the block characteristics of brachial plexus block by supraclavicular approach
Background: Dexmedetomidine, a non-opioid adjuvant to neural blockade supposed to improve the quality of nerve blockade. This study intends to compare the effects of addition of dexmedetomidine as an adjutant to bupivaca...