The efficacy of two different doses of gabapentin (300mg and 600mg) along with NSAID (diclofenac transdermal patch 100mg) in postoperative pain management following abdominal hysterectomy
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 3
Abstract
Context: Gabapentin, an antiepileptic drug has a role in acute postoperative pain management due to its anti hyperalgesic property. Pre-emptive analgesia is the recent concept in multi modal pain management. The purpose was to analyse the effect of Gabapentin as Pre-emptive analgesic.Aim:To study the efficacy and safety of Gabapentin on pain following abdominal hysterectomy and on reduction in Tramadol consumption.Methods and Materials: A randomized, placebo-controlled, double -blind study conducted on 120 ASA I and II patients planned for abdominal hysterectomy. The patients were randomized to receive either oral placebo or Gabapentin 300 mg or Gabapentin 600 mg 1 hour before surgery along with diclofenac transdermal patch 100 mg. Spinal anesthesia was instituted with injection Bupivacaine 0.5% heavy 15mg. Heart Rate, SpO2, Blood pressure, respiratory rate, pain intensity score, rescue analgesic consumption and patient satisfaction score and side effects were recorded. Statistical analysis:Parameters were analysed using one-way ANOVA, Post Hoc LSD test and Chi-Square test. P-value ≤0.05 was considered statistically significant. Results: The pain intensity scores and total Tramadol consumption were significantly reduced in Gabapentin 600 mg group when compared to Gabapentin 300 mg and placebo. The patient satisfaction score was significantly high in Gabapentin 600 mg.Conclusion: Pre-emptive use of Gabapentin (600mg) combined with Diclofenac transdermal patch (100mg) significantly decreases postoperative pain and rescue analgesic requirement, thus provides an effective means of giving postoperative analgesia following abdominal hysterectomy.
Authors and Affiliations
Suresh Rajkumar, V Hari Babu
Keywords
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