A comparative study of dexmedetomidine versus lignocaine used for laryngoscopy and endotracheal intubation with respect to blood pressure changes at tertiary health care centre
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 2
Abstract
Background: Laryngoscopy and endotracheal intubation increase the plasma concentration of catecholamines due to sympathetic stimulation which can result in tachycardia and hypertension in most of the individuals Aims and Objectives : to study of Dexmedetomidine versus lignocaine used for laryngoscopy and endotracheal intubation with respect to Blood pressure changes at tertiary health care centre. Methodology: This was prospective randomized single blind control study carried out in the department of Anesthesia of MIMSR medical college, Latur during the two year period i.e. September 2013 to September 2015 in 80 patients. The patients were divided into Group L- patients receiving i.v. 2 % 1.5 ml/kg lignocaine (preservative free) 3 minute before laryngoscopy. Group D- Patients receiving i.v. dexmedetomide (0.6mcg/kg) 10 minutes before laryngoscopy. The statistical analysis was done by unpaired t-test and calculated by SPSS 19 version. Result: In our study we have seen that Baseline parameters like Systolic Blood pressure, Diastolic Blood pressure, Mean Arterial Pressure were comparable to each other (t=0.15,0.88,NS),(t=0.76,0.76,NS), (t=0.96,0.96,NS) respectively. Systolic Blood pressure was at Baseline (15 min before induction) (t=0.15,0.88,NS); Immediately after induction (t=0.85, 0.4, NS); During intubation (0 minute)(t=4.43,p<0.001,S); 1 minute post intubation (t=2.92, p<0.004,S); 2 minute post intubation (t=2.41p<0.02,S); 3 minute post intubation (t=2.39,p<0.02,S), 4 minute post intubation(t=1.41,0.16,NS);5 minute post intubation(t=0.38,p<0.7,NS); 10 minute post intubation (t=0.73,p<0.47,NS)Diastolic Blood pressure was at Baseline (15 min before induction) (t=0.3,p>0.76,NS); Immediately after induction (t=6.21,p<0.001,S); During intubation (0 minute)(t=8.31,p<0.001,S);1 minute post intubation (t=9.97,p<0.001,S); 2 minute post intubation (t=8.86,p<0.001,S); 3 minute post intubation (t=7.32,p<0.001,S). Conclusion: It can be concluded from our study that intravenous Dexmedetomidine is more effective in attenuating in blood pressure (Systolic, Diastolic, MAP) response to intubation than lignocaine.
Authors and Affiliations
Bhagwan Marotirao Patil, P K Department of Anaesthesia, MIMSR Medical College and Hospital, Latur, Maharashtra, INDIA.
Keywords
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- EP ID EP589648
- DOI 10.26611/10151022
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