A comparative study of dexmedetomidine versus lignocaine used for laryngoscopy and endotracheal intubation with respect to blood pressure changes at tertiary health care centre
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 2
Abstract
Background: Laryngoscopy and endotracheal intubation increase the plasma concentration of catecholamines due to sympathetic stimulation which can result in tachycardia and hypertension in most of the individuals Aims and Objectives : to study of Dexmedetomidine versus lignocaine used for laryngoscopy and endotracheal intubation with respect to Blood pressure changes at tertiary health care centre. Methodology: This was prospective randomized single blind control study carried out in the department of Anesthesia of MIMSR medical college, Latur during the two year period i.e. September 2013 to September 2015 in 80 patients. The patients were divided into Group L- patients receiving i.v. 2 % 1.5 ml/kg lignocaine (preservative free) 3 minute before laryngoscopy. Group D- Patients receiving i.v. dexmedetomide (0.6mcg/kg) 10 minutes before laryngoscopy. The statistical analysis was done by unpaired t-test and calculated by SPSS 19 version. Result: In our study we have seen that Baseline parameters like Systolic Blood pressure, Diastolic Blood pressure, Mean Arterial Pressure were comparable to each other (t=0.15,0.88,NS),(t=0.76,0.76,NS), (t=0.96,0.96,NS) respectively. Systolic Blood pressure was at Baseline (15 min before induction) (t=0.15,0.88,NS); Immediately after induction (t=0.85, 0.4, NS); During intubation (0 minute)(t=4.43,p<0.001,S); 1 minute post intubation (t=2.92, p<0.004,S); 2 minute post intubation (t=2.41p<0.02,S); 3 minute post intubation (t=2.39,p<0.02,S), 4 minute post intubation(t=1.41,0.16,NS);5 minute post intubation(t=0.38,p<0.7,NS); 10 minute post intubation (t=0.73,p<0.47,NS)Diastolic Blood pressure was at Baseline (15 min before induction) (t=0.3,p>0.76,NS); Immediately after induction (t=6.21,p<0.001,S); During intubation (0 minute)(t=8.31,p<0.001,S);1 minute post intubation (t=9.97,p<0.001,S); 2 minute post intubation (t=8.86,p<0.001,S); 3 minute post intubation (t=7.32,p<0.001,S). Conclusion: It can be concluded from our study that intravenous Dexmedetomidine is more effective in attenuating in blood pressure (Systolic, Diastolic, MAP) response to intubation than lignocaine.
Authors and Affiliations
Bhagwan Marotirao Patil, P K Department of Anaesthesia, MIMSR Medical College and Hospital, Latur, Maharashtra, INDIA.
Keywords
Related Articles
- EP ID EP589648
- DOI 10.26611/10151022
- Views 124
- Downloads 0
A study of phrenic nerve paralysis after vertical infraclavicular brachial plexus block
Background: Peripheral nerve blocks are gaining widespread popularity for perioperative management because of their distinct advantages over general and central neuraxial anaesthesia. Infraclavicular brachial plexus bloc...
Hemodynamic changes and post-operative complications with use of caudal bupivacaine and bupivacaine-dexmedetomidine combination for post-operative analgesia
Background: Caudal anaesthesia is a commonly performed regional block in children for abdominal and lower limb surgeries. The use of adjuncts like Dexmedetomidine can effectively help in reduction of the dose and an incr...
Study of intravenously administered dexmedetomidine on isoflurane requirement and perioperative haemodynamic stability in elective surgery
Background and Aims: In this study we observe the effect of dexmedetomidine as an adjuvant to general anesthesia on cardiovascular response to intubation and extubation, hemodynamic stability, requirement of Isoflurane c...
Effect ofintra-articular fentanyl in combination with dexmedetomidine on postoperative analgesia after arthroscopy knee surgery
Background:Dexmedetomedine has been used as sole agent as well as adjuvant to another drug in several studies to enhance postoperative analgesia after knee arthroscopy with an increasedtime for the requirement of first r...
A randomized, prospective, comparative study to evaluate the motor blockade properties of 3ml of 0.5% isobaric levobupivacaine and 3ml of 0.5% isobaric ropivacaine for spinal anaesthesia in patients undergoing elective lower limb orthopaedic surgeries
Background: Levobupivacaine is S (-) enantiomer of bupivacaine. It is somewhat less cardiotoxic than the racemic bupivacaine. It seems to be an attractive alternative to Bupivacaine. Ropivacaine is a long acting regional...