The evaluation of apoptosis in peripheral blood lymphocytes in laryngeal cancer patients
Journal Title: Otolaryngologia Polska - Year 2012, Vol 66, Issue 1
Abstract
SUMMARY The laryngeal cancer is the most often cancer among others in head and neck region. It occurs mostly among 55 and 69. Its development depends on immunological state of the body. Vitality of the immunological system cells was considered due to growth, treatment sensitivity and prognosis of some neoplasms. The aim of this work were estimation and comparison the phenomenon of lymphocytes T and B apoptosis in laryngeal cancer patients treated with surgery and radiotherapy. Material and methods: The material were 30 patients hospitalized in The Department of Otolaryngology Medical University of Lublin. They all were treated with surgery or surgery and radiotherapy. Apoptosis was estimated on different stages of the treatment process. All samples were examined with the flow cytometry method. The control group were 21 patients hospitalized because of the suspicion of the apnea syndrome, which wasn't confirmed with polysomnographic examination. Results: Results of this study show significantly increasing percentage of peripheral blood apoptotic B (CD19+) cells caused by surgical treatment. The results considering radiotherapy showed different influence on the phenomenon of immunological cells apoptosis, still those results weren't significant. Conclusions: The surgical treatment causes increased amount of apoptotic peripheral blood lymphocytes.
Authors and Affiliations
Beata Piechnik, Paulina Wdowiak, Magdalena Wasiak, Sebastian Radej, Agnieszka Lasota, Janusz Klatka
Keywords
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