The expression BIRC6 gene in patients with chronic lymphocytic leukemia
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2014, Vol 27, Issue 3
Abstract
The BIRC6 gene encodes the Bruce (Apollon) protein. This belongs to the III class of Inhibitors of the Apoptosis Protein (IAP) and demonstrates anti-apoptotic activity (binding, inhibiting and degrading the caspases). Moreover, the Bruce protein shows multilevel activities and additional functions. The Bruce protein is involved in the maintenance of cell viability, and it is also suggested that it plays an important role in cell proliferation and diversification. Many researchers have noticed elevated BIRC6 gene expression in cell lines of brain cancer and ovarian carcinoma, leukemia, breast cancer and even in colorectal cancer tissues. Resistance to chemotherapy-inducted apoptosis in cancers characterized by BIRC6 gene over-expression was also reported. The aim of the study was to assess the BIRC6 gene expression in peripheral blood lymphocytes of patients diagnosed with chronic lymphocytic leukemia.
Authors and Affiliations
Piotr Chomik, Paulina Gil-Kulik, Małgorzata Filas, Agnieszka Wojcieszek, Mateusz Wiliński, Jolanta Karwat, Lidia Kotuła, Alicja Niedojadło, Marcin Czop, Anna Bogucka-Kocka, Maria Cioch, Ryszard Pluta, Janusz Kocki
Keywords
Related Articles
- EP ID EP137560
- DOI 10.1515/cipms-2015-0011
- Views 82
- Downloads 0
The international normalized ratio (INR) as seen in a population of patients with atrial fibrillation and cerebral infarction undergoing long-term treatment with vitamin K antagonists
It is estimated that nearly 20% of all cerebral infarctions in the total population are the result of a complication of atrial fibrillation (AF). While oral anticoagulation with vitamin K antagonists (AVKs) substantially...
Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats
This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol adminis...
Cigarette smoking and dental implant tooth replacement therapy: A questionnaire survey among patients receiving implant prosthetic treatment
Chronic nicotinism has negative effects, both local and systemic. Its local effects are related to both the immediate thermal influence, as well as the toxic action of the substances contained in the smoke. In addition,...
The improvement of treatment efficacy of gastropathy associated with the use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori-negative patients with osteoarthritis
Among the more common side effects of osteoarthritis treatment are NSAID-gastropathy and NSAID-enteropathy. NSAIDs can cause direct injury to colon tissue and also impair synthesis of prostaglandins, reduce mucosal integ...
Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations
The binding properties of Eucalyptus gum obtained from the incised trunk of Eucalyptus tereticornis, were evaluated in paracetamol tablet formulations, in comparison with that of Gelatin B.P. In so doing, the compression...