The Factors Influencing Galectin-3 Levels in Acute Coronary Syndrome with Decreased Left Ventricular Function - - - Faktori koji utiču na nivoe galektina-3 kod akutnog koronarnog sindroma sa smanjenom funkcijom leve komore
Journal Title: Acta Facultatis Medicae Naissensis - Year 2017, Vol 34, Issue 4
Abstract
The aim of our study was to determine the factors influencing galectin-3 levels in patients with acute coronary syndrome and decreased left ventricular ejection fraction. We collected material from 37 successive patients with acute coronary syndrome and decreased left ventricular ejection fraction, of which 19 patients had atrial fibrillation, and 18 patients who were without atrial fibrillation constituted a control group. Blood samples used for the biochemical measurements were obtained on the third day from acute coronary syndrome. We used Statistical Package for Social Sciences for data analysis. A p-value less than 0.05 was considered to be a measure of statistical significance. Galectin-3 concentration is directly correlated with age and B-type natriuretic peptide level. Also, our results showed an inverse correlation between galectin-3 and total body weight, body mass index, body surface area and creatinine clearance. The following variables were found to be significant predictors of galectin-3 level: decreased left ventricular ejection fraction, total body weight, LDL concentration and body mass index. We identified factors that can predict a decrease in the left ventricular ejection fraction below 45% after acute coronary syndrome: atrial fibrillation increases the risk by almost six times, and urea concentration increases the risk by 1.2 times for each unit. Left ventricular ejection fraction below 45%, TBW, body mass index and LDL level are good predictors of galectin-3 concentration in patients with ACS and decreased left ventricular ejection fraction. Atrial fibrillation could be a predictive marker of decreased left ventricular ejection fraction. - - - Cilj naše studije bio je da odredimo faktore koji utiču na nivo galektina-3 kod bolesnika sa akutnim koronarnim sindromom i sniženom ejekcionom frakcijom leve komore. Sakupljen je materijal od 37 bolesnika sa akutnim koronarnim sindromom i sniženom ejekcionom frakcijom leve komore, od kojih je 19 imalo atrijalnu fibrilaciju, a 18 bez atrijalne fibrilacije je predstavljalo kontrolnu grupu. Uzorci krvi su uzeti trećeg dana od pojave akutnog koronarnog sindroma. Za analizu podataka smo koristili SPSS (Statistical Package for Social Sciences) softver. P-vrednost manja od 0,05 je smatrana statistički značajnom. Vrednosti galektina-3 su direktno korelirale sa godinama starosti i vrednostima natriuretskog peptide tipa B. Sledeće promenljive su bile značajni prediktori nivoa glaktina-3: snižena ejekciona frakcija leve komore, telesna težina, nivo LDL i indeks telesne mase. Takođe, naši rezultati su pokazali negativnu korelaciju galektina-3 sa ukupnom masom tela, indeksom telesne mase, ukupnom telesnom površinom i klirensom kreatinina. Identifikovali smo faktore koju mogu predvideti pad ejekcione frakcije leve komore ispod 45% nakon akutnog koronarnog sindroma: atrijalna fibrilacija povećava rizik 6 puta, a povećanje koncentracije uree za svaku jednicu 1,2 puta. Ejekciona frakcija leve komore manja od 45%, telena težina, indeks telesne mase i nivo LDL su dobri prediktori koncentracije galektina-3 kod bolesnika sa AKS i sniženom ejekcionom frakcijom. Atrijalna fibrilacija moze poslužiti kao prediktivni marker sniženja ejekcione frakcije leve komore.
Authors and Affiliations
Olivera Andrejić, Rada Vučić, Svetlana Apostolović, Milan Pavlović, Dragana Stokanović, Valentina Nikolić, Tatjana Jevtović-Stoimenov, Stefan Momčilović
Keywords
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- EP ID EP348884
- DOI 10.1515/afmnai-2017-0034
- Views 79
- Downloads 0
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