The Histopathological Effect of Sildenafil Citrate on Superior Colliculus of Adult Male Rat
Journal Title: Journal of Interdisciplinary Histopathology - Year 2013, Vol 1, Issue 4
Abstract
Objective: Preclinical and very limited clinical studies suggest that sildenafil may have therapeutic potential in selected neurological disorders. However, many neurological side effects of sildenafil have been reported. This work aimed to clarify the histopathological effect of sildenafil citrate on the superior colliculus (SC) of adult male albino rat. Material and methods: 24 adult male albino rats were used and divided into 4 groups. The first 3 groups were received respectively sildenafil citrate orally at doses 0.25, 0.70 and 1.43mg/kg body weight daily for 30 days while the 4th group was used as control. At end of the treatment, the superior colliculi were undergone light and electron microscopic investigation. Results: In the control group, superficial part of the SC has neural cells and myelinated nerve fibers. With least dose of sildenafil, the superficial part of SC revealed disturbance in neural tissue with dilated capillaries and vacuoles. Some neurons showed deeply stained nuclei shrunken cytoplasm. Some cells showed enlarged mitochondria and dilated endoplasmic reticulum. With medium dose of sildenafil, SC showed more disturbances; stripped myelin sheaths or widely separated myelin lamellae, dilated blood vessels with large vacuoles around them and many neurons with apoptotic criteria. However, maximum dose of sildenafil induced massive destruction of edematous neural tissue; invasion of the surface with massive blood vessels, marked decrease in thickness of myelin sheaths and the neural cells revealed degenerative and apoptotic changes. The mean number and size of cells revealed significantly progressive decrease in all treated rats with increasing doses of the drug. Conclusion: Long-term, daily use of sildenafil can lead to pathological effect in the superior colliculus which may be implicated in visual disturbance and this effect is dose dependent, so neurological effect of sildenafil necessitates further investigations.
Authors and Affiliations
Amany Shams, Hagar Hashish
Keywords
Related Articles
- EP ID EP156827
- DOI 10.5455/jihp.20130419092832
- Views 97
- Downloads 0
Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
Lateral periodontal cyst (LPC) is an uncommon type of odontogenic cyst of developmental origin that typically occurs laterally on the root surface of a tooth, representing 0.8% - 2% of cysts in the jaws. They are frequen...
Histopathologic Effect of Prenatal Topiramate Exposure on Rat Cerebral Cortex and Hippocampus
Objective: Topiramate is a recent antiepileptic agent approved for treatment of seizure in adults, children and during pregnancy. No much available reports concerning topiramate teratogenic potential in humans. This coul...
C-kit (CD117) expression is not valuable to predict prognosis in invasive ductal carcinoma of breast
Objective: C-kit functions as a tyrosine kinase receptor and represents a target for small molecule kinase inhibitors. The expression pattern for c-kit was studied in different human tumor types as gastrointestinal strom...
Chernobyl-related Bladder Lesions: New Interpretation Required
Some aspects of practical pathology in the former Soviet Union, having a potential impact on the diagnostic quality, as well as possible mechanisms of false-positive diagnostics of malignant and premalignant lesions afte...
Effect of Semicarbazide on the testis of juvenile male albino rat
Background: Semicarbazide (SEM) is an azodicarbonamide byproduct present in a glass jar packaged foods especially baby foods. A relatively high consumption of these products by infants can result in higher exposure compa...