The immune status of cow’s organism after calving under the action of the Hepavex-200

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The immune status of cow’s organism after calving under the action of the Hepavex-200

Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2018, Vol 33, Issue

Abstract

Introduction. In the postpartum period, the use of hepatoprotectors, which increase the resistance of the liver to the influence of pathological factors, restore its functions with various injuries and, also, affect the reproductive system. It is necessary to consider the immune status of the organism when using veterinary preparations that have immunostimulating or immunomodulating properties. The goal of the work was to determine the immune status of cow’s organism after calving and at its correction using preparation Hepavex 200. Materials and methods. Experiment was conducted in LLC “Agroprodservice invest” of Ternopil oblast in dairy cattle of Ukrainian black and white breed. Biochemical studies conducted in the laboratory of veterinary obstetrics and sanitation of Ternopil Research Station of the Institute of Veterinary Medicine of the NAAS. Hepavex 200 was applied to the cows of the experimental group (n = 10) per os on 1-5th day after calving in a dose of 10.0 ml per animal for 5 days. The control group were cows (n = 10) to which preparation was not introduced. Research of cow’s blood for the content of middle mass molecules and sialic acid was conducted before and after application of Hepavex 200. Results of researches and discussion. After preparation “Hepavex 200” application, the level of the circulating immune complexes (CIC) in the cows’ serum reduced by 23.68% (p≤0.01), the Ig M content by 74.55% (p≤0.001), the Ig G by 44.73% (p≤0.01), but the content of Ig A increased by 64.29% (p≤0.001) compared with the initial parameters. The obtained data confirmed the positive effect of the preparation “Hepavex 200” on the state of the humoral component of the organism’s immune system after calving. A significant increase in Ig A in animals promotes the growth of its secretion on the mucous membranes of the reproductive system, provides its protection against various antigens and indicates an increase in local immunity at the organ level. Hepavex 200 application in proposed dose during early postnatal period prevented development of postpartum pathology, open days duration reduced by 72 days (р≤0.01), insemination index by 0,4 unit compared with relevant parameters of cows in control group. Conclusions and prospects for further research. The use of Hepavex 200 in cows on 1-5 days after the calving provides reduction the level of the CIC in serum by 23.68% (p≤0.01), Ig M by 74.55% (p≤0.001), Ig G by 44.73% (p≤0.01) and an increase in the content of Ig A by 64.29% (p≤0.001) compared with the beginning of the study period. The preparation “Hepavex 200” used in cows on 1-5 days after calving ensured a reduction in the open day’s duration by 72 days (p≤0.01), and the insemination index by 0.4 units compared with the corresponding parameters in the control group cows. Our further studies will be focused on the effect of the preparation “Hepavex 200” on the content of liver enzymes of cows in the postpartum period.

Authors and Affiliations

Yaroslav Stravskyy, V. I. Sergeev

Keywords

EP ID EP411593
DOI 10.31073/vet_biotech33-16
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