Abstract

Aim: The widespread increase of mobile telecommunication services is mainly responsible for the amount of radiofrequency radiation (RFR) in public and residential areas. Third generation (3G) is different from second generation (2G) system technologies with respect to carrier frequency. 14-3-3 proteins are a family of highly conserved cellular proteins that plays a crucial role in the regulation of metabolic pathways. Besides 14-3-3 proteins regulate many cellular processes such as cell growth, differentiation and apoptotic cell death. The aim was to study the possible effects of third generation mobile phone base station like Radiofrequency Radiation exposure on the 14-3-3 protein expression in the hepatocellular carcinoma cells (HepG2). Materials and Methods: HepG2 cells were exposed RFR in four different periods as 1 hour, 2, 3 and 4 hours and then western blot analysis was performed to analyse protein expression level. Results: Expressions of 14-3-3 protein were found unaltered in the control, sham and exposure groups. Conclusion: This report presents data about the effects of 3G system technologies mobile phone base station radiation on 14-3-3 protein expression. 14-3-3 isoenzyme analysis and long term exposure experiments should be done to understand the exact effects of 3G mobile phone radiation on HepG2 cell line.

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