The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats
Journal Title: Iranian Journal of Veterinary Science and Technology (IJVST) - Year 2020, Vol 12, Issue 2
Abstract
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is the main regulator in energy metabolism. Training stimulates many processes like mitochondrial biogenesis, glucose metabolism, and fatty acids metabolism. It also increases the capacity of fat oxidation. The purpose of this study was to investigate the effects of eight-week aerobic training of different intensities on PGC-1α, interferon regulatory factor 4 (IRF4), and atherogenic index in obese male Wistar rats. Twenty-four obese male rats induced by a high-fat diet (weight: 250 to 300 gr, BMI >30g/cm2) were divided into three groups: aerobic training of moderate intensity (MI), aerobic training of high intensity (HI), and the control group (C). The MI and HI training groups carried out exercise training by eight weeks of walking on a treadmill for five sessions/week, 60 min per session, and at a speed of 28 m/min and 34 m/min, respectively. The levels of PGC-1a in the MI and HI groups significantly increased compared to the C group (p < 0.05). Moreover, there was no significant differences between IRF4 levels of MI and HI groups (p > 0.05). The serum HDL-C levels increased only in the MI group compared to the C group (p < 0.05). The LDL-C, TG, TC, and atherogenic index levels reduced more significantly in MI and HI groups than in the C group (p < 0.05). The results show that eight-week aerobic training of two moderate and high intensities may be the signaling pathways to the activation of the PGC-1a protein (i.e., a key regulator of energy metabolism and mitochondrial biogenesis) in skeletal muscle.
Authors and Affiliations
Keyvan Hejazi, Mohammad Mosaferi Ziaaldini,, Seyyed Reza Attarzadeh Hosseini, Mehrdad Fathi
Keywords
Related Articles
- EP ID EP722318
- DOI -
- Views 38
- Downloads 1
Growth promoting effects of a multi-strain probiotic on common carp (Cyprinus carpio) fingerlings
Probiotics have shown beneficial effects on growth parameters of various food animals. In this research, the growth promoting effects of a multi-strain probiotic was investigated on common carp (Cyprinus carpio). Accordi...
Establishment of a culture condition for strong proliferation and enrichment of chicken spermatogonial stem cells in vitro
Poultry spermatogonial stem cells (SSCs) have the potential to serve as a model for studying the basic biology of SSC and they can also be used for biotechnological purposes. However, the small number of SSCs and the pre...
The anti-planktonic and anti-biofilm formation activity of Iranian pomegranate peel hydro-extract against Staphylococcus aureus
Staphylococcal infections and contaminations have elicited a growing and perennial concern in the medical and food industries. Meanwhile, the manifestation of antibiotic-resistant strains such as methicillin-resistant St...
The Effects of administration of different parts of banana (Musa cavendish) fruit extracts and peel powder on the oxidative/antioxidative characteristics and some mineral concentrations in neonatal dairy calves
The present study examined the effects of overripe banana (Musa cavendish) pulp and green banana peel extract and powder on oxidants/antioxidants parameters and some minerals in Holstein dairy calves. Forty newborn calve...
A survey of antibiotic residues in commercial eggs in Kermanshah, Iran
Poultry nutrition or inappropriate treatments by antibiotics can lead to production of eggs with antibiotic residues. The aim of the present study is to assess the prevalence of drug residues in eggs presented in Kermans...