The impact of preoperative trimetazidine use on oxidative parameters in patients undergoing coronary bypass surgery
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 4
Abstract
This prospective, randomised, controlled, clinical study was planned to determine the effect of trimetazidine on myocardial ischemia-reperfusion during on pomp coronary artery bypass graft surgery (CABG). Methods: Thirty-five patients undergoing elective CABS in our hospital between 2008 and 2009 were included. The patients were divided into two groups randomly. Seventeen patients consisted trimetazidine group and preoperative trimetazidine PO received for two weeks, whereas 18 cases were controls. Venous blood samples were drawn, preoperatively, intraoperatively and postoperatively, whereas coronary sinus blood samples were drawn before and after cardiopulmonary bypass. At the end, total oxidative status (TOS) and total antioxidant status (TAS) were studied and oxidative stress index (OSİ) was calculated. Repeated measures analysis of variance was used to test the influence of operative stress and trimetazidine use on oxidative parameters. Results: Trimetazidine had no impact on total oxidative status, total antioxidant status and oxidative stress index (p>0.05). However, repeated measurements of total oxidative status, total antioxidant status and oxidative stress index have revealed significant impact of operative stress on oxidative parameters (p<0.05). Conclusion: Preoperative trimetazidine use had no impact on total oxidative status, total antioxidant status and oxidative stress index contrary to significant influence of operative stress on oxidative parameters. Key words: Coronary bypass surgery, trimetazidine, oxidative stress
Authors and Affiliations
Aydemir Koçarslan, Abdüssemet Hazar, Mehmet Aydın, Nurten Aksoy, Mustafa Göz
Keywords
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- EP ID EP125966
- DOI 10.5798/diclemedj.0921.2013.04.0338
- Views 114
- Downloads 0
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