The impact of sterile inflammation in acute liver injury
Journal Title: Journal of Clinical and Translational Research - Year 2017, Vol 3, Issue 1
Abstract
Background: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver injury in a number of models; however, a great deal of controversy and many questions about the nature of sterile inflammation still exist. Aim: The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate. Relevance for patients: Inflammation is one of the most critical factors for managing in-patient liver disease in a number of scenarios. More information is needed for both scientists and clinicians to develop rational treatments.
Authors and Affiliations
Benjamin L. Woolbright, Hartmut Jaeschke
Keywords
Related Articles
- EP ID EP678783
- DOI -
- Views 173
- Downloads 0
Assessment of the Wii Basic Balance Test in measuring postural deficits post-concussion
Background and Aim: To evaluate the Wii Basic Balance Test (WBBT), as a tool for detecting postural instability in athletes with concussions. Methods: Seventy-nine healthy physically active controls (NORM) (mean age 21...
Neonatal circumcision and prematurity are associated with sudden infant death syndrome (SIDS)
Background: Sudden infant death syndrome (SIDS) is the most common cause of postneonatal unexplained infant death. The allostatic load hypothesis posits that SIDS is the result of cumulative perinatal painful, stressful,...
A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging including inflammation, oxidative stress, and DNA damage in healthy adults
Background and Aim: Nutritional approaches that ameliorate cellular senescence may have the potential to counteract the effects of chronic disease. This study will investigate the effect of the Healthycell dietary supple...
Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity
Background: Obesity is often associated with nonalcoholic fatty liver disease (NAFLD), which refers to a large spectrum of hepatic lesions including fatty liver, nonalcoholic steatohepatitis (NASH) and cirrhosis. Differe...
The effect of human amniotic epithelial cells on urethral stricture fibroblasts
Background: Urethral stricture disease (USD) is effectively managed by buccal mucosa (BM) urethroplasty. Lack of adequate healthy BM has led to the use of autologous tissue-engineered BM grafts. Such grafts are costly, n...