The importance of MRD monitoring in intensive treatment for chronic lymphocytic leukemia – a case report
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 6
Abstract
Chronic lymphocytic leukemia is the most common leukemia diagnosed in adults. The median age of diagnosis is 65. The goal of treatment especially in younger patients should be putting them in deep remission, without a minimal residual disease (MRD). The standard currently used to monitor response to treatment does not take into account the status of MRD. The present case-study is of a patient with chronic lymphocytic leukemia diagnosed in a 38 year old. The duration of illness as well as the observation of the patient has now been 13 years. In our case, the effects of each treatment were evaluated not only on the basis of hematological parameters and physical examination but also taking into account the condition of the minimal residual disease. Eliminating pathological CLL cell clones was only after intensive chemotherapy supportive allogeneic haematopietic stem cell transplantation from a related donor.
Authors and Affiliations
Anna Koclęga, Małgorzata Krawczyk-Kuliś, Mirosław Markiewicz, Sławomira Kyrcz-Krzemień
Keywords
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