The In Vivo Antinociceptive and Antiinflammatory Effects of Verbascum exuberans Hub.-Mor.
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 6
Abstract
Objectives: Safe and effective drugs are still lacking for many pain therapies. In recent years, growing interest has been devoted thus on herbal drugs as an option to identify new pain killers. Based on this, extensive researches are carried out on Verbascum L. genus due to its therapeutic potency on pain and inflammation therapy. In this study, among Verbascum species, the antinociceptive effect of Verbascum exuberans Hub.-Mor., and its contributions to nitrergic, serotonergic, or opioidergic pathways as well as its antiinflammatory acitivity were investigated. Materials and Methods: Tail clip, tail flick, and hot plate tests were used to determine the central (spinal and supraspinal) antinociceptive effect, while an acetic acid-induced writhing test was used to measure the peripheral antinociceptive effect of the extract (250 and 500 mg/kg). The extract (250 mg/kg) was then combined with nω-nitro-L-arginine methyl ester, cyproheptadine, and naloxone to evaluate its involvement in nitrergic, serotonergic, or opioidergic pathways, respectively. Carrageenan-induced hind paw edema model was used to determine the antiinflammatory effect of the extract (250 mg/kg). Results: The extract shows central spinal but not central supraspinal antinociceptive effect, and presents peripheral antinociceptive effect. The antinociceptive actions of the extract is largely regulated via targeting the nitrergic pathway, while the opioidergic pathway is partly involved. Further, the extract shows antiinflammatory effect due to the significant inhibitions on the time dependent edema progression and the cytokine (tumor necrosis factor-alfa and interleukin-1beta) productions. Conclusion: V. exuberans could be stated as a new source with a high beneficial potential in alleviating pain and inflammation.
Authors and Affiliations
Esra EYİİŞ, Bilgin KAYGISIZ, Fatma Sultan KILIÇ, Adnan AYHANCI
Keywords
Related Articles
- EP ID EP691688
- DOI 10.4274/tjps.galenos.2019.77992
- Views 115
- Downloads 0
Pyrophen Isolated from the Endophytic Fungus Aspergillus fumigatus Strain KARSV04 Synergizes the Effect of Doxorubicin in Killing MCF7 but not T47D Cells
Objectives: Pyrophen, an amino acid-pyrone derivative isolated from Aspergillus fumigatus strain KARSV04 has been reported to have an anticancer effect on T47D cells by inhibiting the growth of cells and modulating the c...
The In Vivo Antinociceptive and Antiinflammatory Effects of Verbascum exuberans Hub.-Mor.
Objectives: Safe and effective drugs are still lacking for many pain therapies. In recent years, growing interest has been devoted thus on herbal drugs as an option to identify new pain killers. Based on this, extensive...
QSAR Studies on Neuraminidase Inhibitors as Anti-influenza Agents
Objectives: The present study aimed to establish significant and validated quantitative structure-activity relationship (QSAR) models for neuraminidase inhibitors and correlate their physicochemical, steric, and electros...
Current Overview of Oral Thin Films
The pharmaceutical industry is attempting to discover thin films as a new drug delivery system. Thin films have been described as an alternative approach to conventional dosage forms. They are a versatile platform that p...
Cytotoxic Activity of Sesquiterpenoids Isolated from Endemic Ferula tenuissima Hub.-Mor & Peşmen
Objectives: This was a phytochemical study of endemic Ferula tenuissima roots and determined the cytotoxic activity of pure compounds on PC-3. Materials and Methods: Air-dried and powdered roots of F. tenuissima (1 kg)...