THE INCREASING OF VEGF EXPRESSION AND RE-EPITHELIALIZATION ON DERMAL WOUND HEALING PROCESS AFTER TREATMENT OF BANANA PEEL EXTRACT (MUSA ACUMINATA COLLA)
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: The objective of the study was to determine the efficacy of topical administration of an alcoholic bark extract of Musa acuminata Colla on cutaneous wound healing including expression of VEGF and re-epithelization on dermal in rats.Methods: Model was performed to evaluate the excision model of wound healing activity. Full-thickness excision wounds were made on the back of rat and Musa acuminata Colla extract was topically administered (doses 25%, 50% & 75%). The formation of granulation tissue was observed on day 4, 8, 12 and 16 (post-wound) to indicate VEGF and collagen. The extract increased cellular re-epithelialisation and collagen synthesis at the wound site, shown by increase in VEGF, and total collagen content of granulation tissues. The rate of contraction in wounds was determined by tracing the wound surface onto a transparent graph paper and measuring the surface area by planimetry.Results: From the observation in EBP, all doses were found to have wound healing activity in wound contraction and period of epithelialization. The increasing of VEGF expression was found greater in the extract treated group than control group. The tensile strength of extract treated group was increased significantly.Conclusion: The results indicated that Musa acuminata Colla peel extracts has significant wound healing activity.
Authors and Affiliations
Rosida Hariyadi, Sukardiman . , Junaidi Khotib
Keywords
Related Articles
- EP ID EP579334
- DOI -
- Views 67
- Downloads 0
QBD-BASED DEVELOPMENT AND EVALUATION OF ENTERIC COATED MUCOADHESIVE MICROCAPSULES OF AMOXICILLIN TRIHYDRATE AS A NOVEL CHRONOTHERAPEUTIC APPROACH FOR TREATMENT OF BACTERIAL INFECTIONS
Objective:Â The present work entails design and characterization of enteric coated mucoadhesive microcapsules loaded with amoxicillin trihydrate as a novel chronotherapeutic approaches for the treatment and management of...
IN VITRO ANTI-OBESITY EFFECT OF MACROLICHENS HETERODERMIA LEUCOMELOS AND RAMALINA CELASTRI BY PANCREATIC LIPASE INHIBITORY ASSAY
Objective: Obesity is a chronic disorder caused by an imbalance between energy intake and expenditure in which excessive fat will be deposited in adipose tissue and poses a risk to the health and well-being of humans. Ag...
OPINION AND EXPECTATION OF PHARMACISTS ON PROVIDING EXTEMPORANEOUS COMPOUNDING IN JOGJAKARTA AND CENTRAL JAVA PROVINCES, INDONESIA
Objective: This study was conducted to identify opinion and expectations of pharmacists on providing extemporaneous drug compounding to support pharmacy service. Methods: The study was conducted in Indonesia. Twenty phar...
DRAFT GENOME SEQUENCE OF HUMAN HERPES VIRUS-4 VRF_EBV_01, AN EPSTEIN BARR VIRUS OBTAINED FROM A PEDIATRIC POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER (PTLD) PATIENT
Objectives: To decode the sequence of Epstein-barr virus (EBV) genome isolated from a pediatric patient with post transplant lymphoproliferative disorder (PTLD).Methods: EBV culture harvested from the blood sample of a 4...
FORMULATION, EVALUATION AND SOLID-STATE THERMOGRAPHIC CHARACTERIZATION OF CFC FREE BECLOMETASONE DIPROPIONATE PRESSURIZED METERED DOSE INHALATION
Objective: In view of the aim, the objective of the present work was to develop a solution based pulmonary drug delivery system containing Beclometasone dipropionate 250mcg using a Hydrofluoroalkane (HFA 134a and HFA 227...