The influence of atypical antipsychotics on brain functioning in schizophrenia. A proton magnetic resonance study
Journal Title: Psychiatria Polska - Year 2010, Vol 44, Issue 3
Abstract
Introduction. The influence of antipsychotic medication on brain alterations in proton magnetic resonance spectroscopy (1H MRS) in schizophrenia can be the explanation of many discrepancies observed in the previous papers. Aim. The aim of this study was the evaluation of antipsychotic medication effect on the metabolite levels in the brain of schizophrenic patients based on 1H MRS examination. Methods. The group of 32 patients with a diagnosis of schizophrenia according to DSM-IV and 26 healthy controls were included into the study. The patients were examined twice – once after the period of at least 7 days without neuroleptics (baseline) and for the second time at least 4 weeks after stable doses of neuroleptics (follow-up). 21 patients were receiving risperidone and 11 – olanzapine. Proton resonance spectroscopy was performed on a 1.5 MR scanner. Each volume element (voxel) was localised in the left frontal lobe, in the left temporal lobe and in the left thalamus. Metabolite ratios: N-acetylaspartate (NAA) to creatine (Cr) and unsupressed water signal were analysed. Results. We found the significant increase of the NAA/Cr level in the thalamus in the group of patients treated with risperidone, we didn’t observe similar changes in the olanzapine group. Conclusions. Our results confirm that the neuroleptic drugs, especially atypicals, modify brain metabolism measured by 1H MRS. The pattern of the changes suggest a possible neuroprotective influence of the antipsychototic treatment in schizophrenic patients. The small group of the olanzapine treated patients doses not allow to make any conclusions regarding this type of medication.
Authors and Affiliations
Agata Szulc, Beata Galińska, Eugeniusz Tarasów, Wojciech Dzienis, Bożena Kubas, Napoleon Waszkiewicz, Regina Popławska
Keywords
Related Articles
- EP ID EP150034
- DOI -
- Views 73
- Downloads 0
The Euro-orphans phenomenon and the courses in therapeutic work and psychiatric treatment – a case study
to children with one or both parents emigrated from the country for work purposes. In connection with the social transformations of orphan-hood types described in the literature (nature, spiritual, social), the definitio...
Extraction techniques for analysis of venlafaxine and its metabolites in biological matrices
Venlafaxine (VEN), which was introduced into therapy in 1990s is one of the most often used antidepressants. The monitoring of its concentration in the organism is recommended, particularly in the case when a patient suf...
Oxytocin model of formation of psychotic symptoms and its implications for research on oxytocinergic pathway in schizophrenia
There are more and more data to support the dysregulation of the oxytocinergic pathway in schizophrenia. The development of the above branch of knowledge began to evolve alongside the mainstream of studies concerning gen...
List do redakcji. Różnice w treści ulotek leków zawierających zolpidem
The participation of patients with schizophrenia in psychoeducation – the analysis from the patients’ perspective
Aim. The aim of this study was to find out what the patients opinion about psychoeducation in schizophrenia is. Method. We examined 169 patients suffering from schizophrenia. They answered a questionnaire about demograp...