The interaction of Candida albicans with C-type lectin receptors
Journal Title: Perioperative Precision Medicine - Year 2023, Vol 1, Issue 1
Abstract
Candida albicans (C. albicans) is a ubiquitous commensal in the mammalian flora and the most prevalent fungal pathogen of humans. As an opportunistic fungus, C. albicans can cause mucosal and invasive infections. Invasive candidiasis infected by C. albicans is a leading cause of perioperative death in immunocompromised and immunodeficient patients. The morphological change from the yeast to the mycelium plays a key role in the pathogenesis of C. albicans. C-type lectin receptors (CLRs), including Dectin-1, Dectin-2, Dectin-3, Mincle, and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin, are among the pattern recognition receptors expressed by innate immune cells that can recognize C. albicans. The emergence of drug-resistant C. albicans put pressure on the healthcare system, whereby CLRs have also attracted extensive attention from physicians. Thus, in this article, we discuss the interaction between CLRs and C. albicans and the treatment prospects of CLRs on anti-C. albicans.
Authors and Affiliations
Lindong Cheng, Ping Li, Duy Khanh La, Zhen Xing, Chunhua Liao
Keywords
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- EP ID EP749856
- DOI 10.61189/863627autews
- Views 27
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