The interaction of Candida albicans with C-type lectin receptors
Journal Title: Perioperative Precision Medicine - Year 2023, Vol 1, Issue 1
Abstract
Candida albicans (C. albicans) is a ubiquitous commensal in the mammalian flora and the most prevalent fungal pathogen of humans. As an opportunistic fungus, C. albicans can cause mucosal and invasive infections. Invasive candidiasis infected by C. albicans is a leading cause of perioperative death in immunocompromised and immunodeficient patients. The morphological change from the yeast to the mycelium plays a key role in the pathogenesis of C. albicans. C-type lectin receptors (CLRs), including Dectin-1, Dectin-2, Dectin-3, Mincle, and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin, are among the pattern recognition receptors expressed by innate immune cells that can recognize C. albicans. The emergence of drug-resistant C. albicans put pressure on the healthcare system, whereby CLRs have also attracted extensive attention from physicians. Thus, in this article, we discuss the interaction between CLRs and C. albicans and the treatment prospects of CLRs on anti-C. albicans.
Authors and Affiliations
Lindong Cheng, Ping Li, Duy Khanh La, Zhen Xing, Chunhua Liao
Keywords
Related Articles
- EP ID EP749856
- DOI 10.61189/863627autews
- Views 4
- Downloads 0
Roles of post-translational modifications of C-type lectin receptor-induced signaling cascades in innate immune responses against Candida albicans
Candida albicans (C. albicans), a conditional pathogenic fungus, is widespread in nature and can live in symbiosis with organisms in small quantities. When the normal microflora is imbalanced, the epithelial barrier is d...
Research progress of oxidative stress in sepsis-associated liver injury
Sepsis is a systemic inflammatory response that caused by infection or trauma, often resulting in multiple organ dysfunction. Its mortality rate is relatively high, ranging between 54% and 68%, and ineffective treatment...
MicroRNAs: Regulators of the host antifungal immune response
Fungi pose a severe threat to human health worldwide, especially to patients with weakened immune systems. Perioperative patients are at a high risk of fungal infection and death because of the immunosuppression caused b...
Effects of general anesthetics on the cognitive function of pediatric patients: A review
The consequences induced by the use of general anesthetics and better options of the drugs in children and infants have been topics of controversy due to the concerns about their potential impact on cognitive function. T...
Medical image processing using graph convolutional networks: A review
Deep learning, especially graph convolutional networks (GCNs), has been widely applied in various scenarios. Particularly in the field of medical image processing, the research on GCNs have continued to make breakthrough...